Mikael Widersten
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Explore the profile of Mikael Widersten including associated specialties, affiliations and a list of published articles.
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Articles
42
Citations
256
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Recent Articles
1.
Acevedo-Rocha C, Berlicki L, Bornscheuer U, Campopiano D, Chaiyen P, civic J, et al.
Faraday Discuss
. 2024 Aug;
252(0):127-156.
PMID: 39177511
No abstract available.
2.
Hebert H, Sonmez E, Purhonen P, Widersten M
Structure
. 2024 Jul;
32(9):1322-1326.e4.
PMID: 39013461
Two structures of fructose 6-phosphate aldolase, the wild-type and an engineered variant containing five active-site mutations, have been solved by cryoelectron microscopy (cryo-EM). The engineered variant affords production of aldols...
3.
Blazic M, Gautier C, Norberg T, Widersten M
Faraday Discuss
. 2024 Jun;
252(0):115-126.
PMID: 38828992
Epoxide hydrolase StEH1, from potato, is similar in overall structural fold and catalytic mechanism to haloalkane dehalogenase DhlA from . StEH1 displays low (promiscuous) hydrolytic activity with (2-chloro)- and (2-bromo)ethanebenzene...
4.
Sridhar S, Kiema T, Schmitz W, Widersten M, Wierenga R
FEBS Open Bio
. 2024 Mar;
14(4):655-674.
PMID: 38458818
Multifunctional enzyme, type-1 (MFE1) catalyzes the second and third step of the β-oxidation cycle, being, respectively, the 2E-enoyl-CoA hydratase (ECH) reaction (N-terminal part, crotonase fold) and the NAD-dependent, 3S-hydroxyacyl-CoA dehydrogenase...
5.
Sridhar S, Zavarise A, Kiema T, Dalwani S, Eriksson T, Hajee Y, et al.
IUCrJ
. 2023 Jun;
10(Pt 4):437-447.
PMID: 37261425
The Fe-dependent E. coli enzyme FucO catalyzes the reversible interconversion of short-chain (S)-lactaldehyde and (S)-1,2-propanediol, using NADH and NAD as cofactors, respectively. Laboratory-directed evolution experiments have been carried out previously...
6.
Zavarise A, Sridhar S, Kiema T, Wierenga R, Widersten M
FEBS J
. 2022 Aug;
290(2):465-481.
PMID: 36002154
A group-III iron containing 1,2-propanediol oxidoreductase, FucO, (also known as lactaldehyde reductase) from Escherichia coli was examined regarding its structure-dynamics-function relationships in the catalysis of the NADH-dependent reduction of (2S)-lactaldehyde....
7.
Facile synthesis of 2-hydroxyacetophenone from racemic styrene oxide catalyzed by engineered enzymes
Soderlund I, Tjarnhage E, Hamnevik E, Widersten M
Biotechnol Lett
. 2022 Jun;
44(8):985-990.
PMID: 35731351
We describe a system that allows for biocatalyzed in vivo synthesis of α-hydroxy ketones from racemic epoxide starting material by in vivo co-expression of native and engineered epoxide hydrolase and...
8.
van der Ent F, Lund B, Svalberg L, Purg M, Chukwu G, Widersten M, et al.
Biochemistry
. 2022 May;
61(10):933-942.
PMID: 35503728
The structural origin of enzyme cold-adaptation has been the subject of considerable research efforts in recent years. Comparative studies of orthologous mesophilic-psychrophilic enzyme pairs found in nature are an obvious...
9.
Widersten M
Methods Enzymol
. 2020 Sep;
644:149-167.
PMID: 32943143
Formation of carbon-carbon bonds is central to synthetic chemistry. The aldol reaction provides the chemistry to fuse a nucleophilic enolate with an electrophilic aldehyde to form a new CC bond...
10.
Al-Smadi D, Reddy Enugala T, Kessler V, Mhashal A, Kamerlin S, Kihlberg J, et al.
J Org Chem
. 2019 May;
84(11):6982-6991.
PMID: 31066559
Polyhydroxylated compounds are building blocks for the synthesis of carbohydrates and other natural products. Their synthesis is mainly achieved by different synthetic versions of aldol-coupling reactions, catalyzed either by organocatalysts,...