Mikael Lerner
Overview
Explore the profile of Mikael Lerner including associated specialties, affiliations and a list of published articles.
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11
Citations
395
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Recent Articles
1.
Dyczynski M, Yu Y, Otrocka M, Parpal S, Braga T, Henley A, et al.
Cancer Lett
. 2018 Jul;
435:32-43.
PMID: 30055290
Resistance to chemotherapy is a challenging problem for treatment of cancer patients and autophagy has been shown to mediate development of resistance. In this study we systematically screened a library...
2.
Xu L, Muller S, Thoppe S, Hellborg F, Kanter L, Lerner M, et al.
PLoS One
. 2014 Nov;
9(11):e111125.
PMID: 25379706
The p53 target gene WIG-1 (ZMAT3) is located in chromosomal region 3q26, that is frequently amplified in human tumors, including cervical cancer. We have examined the status of WIG-1 and...
3.
Cepeda D, Ng H, Sharifi H, Mahmoudi S, Cerrato V, Fredlund E, et al.
EMBO Mol Med
. 2013 Jun;
5(7):1067-86.
PMID: 23776131
SCF (Skp1/Cul1/F-box) ubiquitin ligases act as master regulators of cellular homeostasis by targeting key proteins for ubiquitylation. Here, we identified a hitherto uncharacterized F-box protein, FBXO28 that controls MYC-dependent transcription...
4.
Gatt M, Takada K, Mani M, Lerner M, Pick M, Hideshima T, et al.
Br J Haematol
. 2013 May;
162(2):210-20.
PMID: 23647456
Multiple myeloma (MM) is an incurable neoplasm caused by proliferation of malignant plasma cells in the bone marrow (BM). MM is characterized frequently by a complete or partial deletion of...
5.
Lerner M, Haneklaus M, Harada M, Grander D
PLoS One
. 2012 May;
7(5):e36490.
PMID: 22615771
The pro-apoptotic p53 target Noxa is a BH3-only protein that antagonizes the function of selected anti-apoptotic Bcl-2 family members. While much is known regarding the transcriptional regulation of Noxa, its...
6.
Lerner M, Lundgren J, Akhoondi S, Jahn A, Ng H, Akbari Moqadam F, et al.
Cell Cycle
. 2011 May;
10(13):2172-83.
PMID: 21597324
The F-box protein FBW7/hCDC4 is a tumor suppressor that acts as the substrate recognition component of an SCF ubiquitin ligase that targets numerous oncoproteins for proteasomal degradation. In this study,...
7.
Lerner M, Harada M, Loven J, Castro J, Davis Z, Oscier D, et al.
Exp Cell Res
. 2009 Jul;
315(17):2941-52.
PMID: 19591824
The microRNAs miR-15a and miR-16-1 are downregulated in multiple tumor types and are frequently deleted in chronic lymphocytic leukemia (CLL), myeloma and mantle cell lymphoma. Despite their abundance in most...
8.
Lerner M, Corcoran M, Cepeda D, Nielsen M, Zubarev R, Ponten F, et al.
Mol Biol Cell
. 2007 Feb;
18(5):1670-82.
PMID: 17314412
RFP2, a gene frequently lost in various malignancies, encodes a protein with RING finger, B-box, and coiled-coil domains that belongs to the RBCC/TRIM family of proteins. Here we demonstrate that...
9.
Weng W, Lerner M, Grander D, Ahlen J, Villablanca A, Pang S, et al.
Int J Oncol
. 2004 Dec;
26(1):5-16.
PMID: 15586219
Soft tissue sarcomas (STSs) arising in the abdominal cavity constitute a group of aggressive tumours, typically of very large size and with a high recurrence rate in the affected patients....
10.
Hammarsund M, Lerner M, Zhu C, Merup M, Jansson M, Gahrton G, et al.
Hum Mol Genet
. 2004 Oct;
13(23):2925-36.
PMID: 15459180
Karyotypical alteration of chromosome 5 and in particular band 5q13 is a frequent finding in hairy cell leukemia (HCL). We have previously identified a number of candidate genes localized in...