Miho Iijima
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Explore the profile of Miho Iijima including associated specialties, affiliations and a list of published articles.
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Recent Articles
21.
Murata D, Yamada T, Tokuyama T, Arai K, Quiros P, Lopez-Otin C, et al.
EMBO J
. 2020 Nov;
39(24):e105074.
PMID: 33200421
The connectivity of mitochondria is regulated by a balance between fusion and division. Many human diseases are associated with excessive mitochondrial connectivity due to impaired Drp1, a dynamin-related GTPase that...
22.
Adachi Y, Kato T, Yamada T, Murata D, Arai K, Stahelin R, et al.
Mol Cell
. 2020 Nov;
80(4):621-632.e6.
PMID: 33152269
Mitochondria are highly dynamic organelles that continuously grow, divide, and fuse. The division of mitochondria is crucial for human health. During mitochondrial division, the mechano-guanosine triphosphatase (GTPase) dynamin-related protein (Drp1)...
23.
Kato T, Yamada T, Nakamura H, Igarashi A, Anders R, Sesaki H, et al.
iScience
. 2020 Oct;
23(10):101548.
PMID: 33083717
The gene is highly mutated in many cancers, including hepatocellular carcinoma. The PTEN protein is located at different subcellular regions-PTEN at the plasma membrane suppresses PI3-kinase signaling in cell growth,...
24.
Murata D, Arai K, Iijima M, Sesaki H
J Biochem
. 2019 Dec;
167(3):233-241.
PMID: 31800050
The mitochondrion is an essential organelle for a wide range of cellular processes, including energy production, metabolism, signal transduction and cell death. To execute these functions, mitochondria regulate their size,...
25.
Itoh K, Murata D, Kato T, Yamada T, Araki Y, Saito A, et al.
Elife
. 2019 Oct;
8.
PMID: 31603426
Dynamin-related protein 1 (Drp1) divides mitochondria as a mechano-chemical GTPase. However, the function of Drp1 beyond mitochondrial division is largely unknown. Multiple Drp1 isoforms are produced through mRNA splicing. One...
26.
SQSTM1/p62 promotes mitochondrial ubiquitination independently of PINK1 and PRKN/parkin in mitophagy
Yamada T, Dawson T, Yanagawa T, Iijima M, Sesaki H
Autophagy
. 2019 Jul;
15(11):2012-2018.
PMID: 31339428
The ubiquitination of mitochondrial proteins labels damaged mitochondria for degradation through mitophagy. We recently developed an system in which mitophagy is slowed by inhibiting mitochondrial division through knockout of ,...
27.
Senoo H, Kamimura Y, Kimura R, Nakajima A, Sawai S, Sesaki H, et al.
Nat Cell Biol
. 2019 Jul;
21(7):867-878.
PMID: 31263268
mTORC2 plays critical roles in metabolism, cell survival and actin cytoskeletal dynamics through the phosphorylation of AKT. Despite its importance to biology and medicine, it is unclear how mTORC2-mediated AKT...
28.
Yamada T, Murata D, Adachi Y, Itoh K, Kameoka S, Igarashi A, et al.
Cell Metab
. 2018 Jul;
28(4):588-604.e5.
PMID: 30017357
It is unknown what occurs if both mitochondrial division and fusion are completely blocked. Here, we introduced mitochondrial stasis by deleting two dynamin-related GTPases for division (Drp1) and fusion (Opa1)...
29.
Kriebel P, Majumdar R, Jenkins L, Senoo H, Wang W, Ammu S, et al.
J Cell Biol
. 2018 Jun;
217(8):2891-2910.
PMID: 29884750
Chemotactic signals are relayed to neighboring cells through the secretion of additional chemoattractants. We previously showed in that the adenylyl cyclase A, which synthesizes the chemoattractant cyclic adenosine monophosphate (cAMP),...
30.
Itoh K, Adachi Y, Yamada T, Suzuki T, Otomo T, McBride H, et al.
J Biol Chem
. 2018 Jun;
293(30):11809-11822.
PMID: 29853636
Dynamin-related protein 1 (Drp1) constricts mitochondria as a mechanochemical GTPase during mitochondrial division. The Drp1 gene contains several alternative exons and produces multiple isoforms through RNA splicing. Here we performed...