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Miho Iijima

Explore the profile of Miho Iijima including associated specialties, affiliations and a list of published articles. Areas
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Articles 82
Citations 3803
Followers 0
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Recent Articles
11.
Yeung N, Iijima M, Sesaki H
Proc Natl Acad Sci U S A . 2022 Dec; 119(51):e2217949119. PMID: 36508657
No abstract available.
12.
Murata D, Grunseich C, Iijima M, Chan D, Corse A, Hoke A, et al.
J Neuromuscul Dis . 2022 Oct; 10(1):107-118. PMID: 36314214
Background: The number of mutations in nuclear encoded genes causing mitochondrial disease is ever increasing. Identification of these mutations is particularly important in the diagnosis of neuromuscular disorders as their...
13.
Yamada T, Murata D, Kleiner D, Anders R, Rosenberg A, Kaplan J, et al.
iScience . 2022 Mar; 25(4):103996. PMID: 35310936
Non-alcoholic steatohepatitis (NASH) is a most common chronic liver disease that is manifested by steatosis, inflammation, fibrosis, and tissue damage. Hepatocytes produce giant mitochondria termed megamitochondria in patients with NASH....
14.
Kato T, Igarashi A, Sesaki H, Iijima M
Genes Cells . 2021 Oct; 26(12):1014-1022. PMID: 34661323
Many human diseases, including cancer and neurological abnormalities, are linked to deficiencies of phosphatase and tensin homolog deleted on chromosome ten (PTEN), a dual phosphatase that dephosphorylates both lipids and...
15.
Senoo H, Murata D, Wai M, Arai K, Iwata W, Sesaki H, et al.
Mol Cell . 2021 Sep; 81(22):4622-4634.e8. PMID: 34551282
AKT is a serine/threonine kinase that plays an important role in metabolism, cell growth, and cytoskeletal dynamics. AKT is activated by two kinases, PDK1 and mTORC2. Although the regulation of...
16.
Song B, Gu Y, Jiang W, Li Y, Nishio Ayre W, Liu Z, et al.
Cell Biosci . 2021 Jul; 11(1):139. PMID: 34289909
No abstract available.
17.
Song B, Gu Y, Jiang W, Li Y, Nishio Ayre W, Liu Z, et al.
Cell Biosci . 2021 Jun; 11(1):111. PMID: 34127068
Background: Cells show directed migration response to electric signals, namely electrotaxis or galvanotaxis. PI3K and PTEN jointly play counterbalancing roles in this event via a bilateral regulation of PIP3 signaling....
18.
Igarashi A, Kato T, Sesaki H, Iijima M
Biochem Biophys Res Commun . 2021 Apr; 555:81-88. PMID: 33813280
Defects in PTEN, a critical tumor suppressor, are associated with tumorigenesis and aberrant organ sizes. It has been shown that heterozygous PTEN loss increases brains and neuron size, while the...
19.
Kato T, Murata D, Anders R, Sesaki H, Iijima M
Biochem Biophys Res Commun . 2021 Mar; 549:83-90. PMID: 33667713
PTEN and p53 are highly mutated in many cancers. These two tumor suppressors have critical functions in the nucleus, such as DNA repair, cell cycle progression, and genome maintenance. However,...
20.
Senoo H, Wai M, Matsubayashi H, Sesaki H, Iijima M
Cell Rep . 2020 Nov; 33(8):108427. PMID: 33238110
The activation of G-protein-coupled receptors (GPCRs) leads to the activation of mTORC2 in cell migration and metabolism. However, the mechanism that links GPCRs to mTORC2 remains unknown. Here, using Dictyostelium...