Miho Iijima
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Explore the profile of Miho Iijima including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Yamada T, Ikeda A, Murata D, Wang H, Zhang C, Khare P, et al.
Nature
. 2025 Feb;
PMID: 39972141
Mitochondrial stress pathways protect mitochondrial health from cellular insults. However, their role under physiological conditions is largely unknown. Here, using 18 single, double and triple whole-body and tissue-specific knockout and...
2.
Ito F, Iwata W, Adachi Y, Sesaki H, Iijima M
Front Cell Dev Biol
. 2025 Feb;
12:1511190.
PMID: 39897079
Epidermal growth factor receptor (EGFR) is a major oncogenic protein, and thus EGFR-targeting therapies are widely used in patients with various types of cancer, including lung cancer. However, resistance to...
3.
Erratum: mCAUSE: Prioritizing mitochondrial targets that alleviate pancreatic cancer cell phenotypes
Murata D, Ito F, Tang G, Iwata W, Yeung N, West J, et al.
iScience
. 2025 Jan;
27(11):111146.
PMID: 39759081
[This corrects the article DOI: 10.1016/j.isci.2024.110880.].
4.
Murata D, Ito F, Tang G, Iwata W, Yeung N, West J, et al.
iScience
. 2024 Sep;
27(9):110880.
PMID: 39310760
Substantial changes in energy metabolism are a hallmark of pancreatic cancer. To adapt to hypoxic and nutrient-deprived microenvironments, pancreatic cancer cells remodel their bioenergetics from oxidative phosphorylation to glycolysis. This...
5.
Murata D, Roy S, Lutsenko S, Iijima M, Sesaki H
Dev Cell
. 2024 Jul;
59(19):2578-2592.e7.
PMID: 38986607
Following the Goldilocks principle, mitochondria size must be "just right." Mitochondria balance division and fusion to avoid becoming too big or too small. Defects in this balance produce dysfunctional mitochondria...
6.
Ikeda A, Iijima M, Sesaki H
iScience
. 2024 May;
27(6):109874.
PMID: 38784001
Mitochondrial division controls the size, distribution, and turnover of this essential organelle. A dynamin-related GTPase, Drp1, drives membrane division as a force-generating mechano-chemical enzyme. Drp1 is regulated by multiple mechanisms,...
7.
Ramatchandirin B, Iijima M, Ikeda A, Pearah A, Radovick S, Wondisford F, et al.
STAR Protoc
. 2024 Jan;
5(1):102842.
PMID: 38244201
Mitochondrial dynamic process is important for cell viability, metabolic activity, and mitochondria health. Here, we present a protocol for measuring mitochondrial size through immunofluorescence staining, confocal imaging, and analysis in...
8.
Ikeda A, Iijima M, Sesaki H
J Cell Biol
. 2023 Sep;
222(10).
PMID: 37707790
Mitochondrial fusion plays an important role in both their structure and function. In this issue, Su et al. (2023. J. Cell Biol.https://doi.org/10.1083/jcb.202301091) report that a nucleoside diphosphate kinase, NME3, facilitates...
9.
Yeung N, Murata D, Iijima M, Sesaki H
iScience
. 2023 Feb;
26(2):106067.
PMID: 36818283
The human mtHSP60/HSPD1-mtHSP10/HSPE1 system prevents protein misfolding and maintains proteostasis in the mitochondrial matrix. Altered activities of this chaperonin system have been implicated in human diseases, such as cancer and...
10.
Hayashida R, Kikuchi R, Imai K, Kojima W, Yamada T, Iijima M, et al.
J Biol Chem
. 2022 Dec;
299(2):102822.
PMID: 36563856
RING-between RING (RBR)-type ubiquitin (Ub) ligases (E3s) such as Parkin receive Ub from Ub-conjugating enzymes (E2s) in response to ligase activation. However, the specific E2s that transfer Ub to each...