Michelle S Johnson
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Explore the profile of Michelle S Johnson including associated specialties, affiliations and a list of published articles.
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49
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2189
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Recent Articles
1.
Kane M, Benavides G, Osuma E, Johnson M, Collins H, He Y, et al.
Sci Rep
. 2023 Dec;
13(1):21638.
PMID: 38062139
Mitochondria morphology and function, and their quality control by mitophagy, are essential for heart function. We investigated whether these are influenced by time of the day (TOD), sex, and fed...
2.
Jindal T, Zhu X, Bose R, Kumar V, Maldonado E, Deshmukh P, et al.
Front Oncol
. 2023 Apr;
13:1161089.
PMID: 37091148
Background: Enfortumab vedotin (EV) is an antibody-drug conjugate approved for patients with treatment-refractory advanced urothelial carcinoma (aUC), however data on biomarkers of response is lacking. Methods: We retrospectively identified all...
3.
Xing D, Benavides G, Johnson M, Tian R, Barnes S, Darley-Usmar V
Nitric Oxide
. 2022 Nov;
130:22-35.
PMID: 36414197
Limited O availability can decrease essential processes in energy metabolism. However, cancers have developed distinct metabolic adaptations to these conditions. For example, glutaminolysis can maintain energy metabolism and hypoxia signaling....
4.
Mueller T, Ouyang X, Johnson M, Qian W, Chatham J, Darley-Usmar V, et al.
Front Aging
. 2022 Jul;
1:620382.
PMID: 35822169
O-GlcNAcylation is a protein posttranslational modification that results in the addition of O-GlcNAc to Ser/Thr residues. Since its discovery in the 1980s, it has been shown to play an important...
5.
Huynh V, Wang S, Ouyang X, Wani W, Johnson M, Chacko B, et al.
Front Aging
. 2022 Jul;
2:757801.
PMID: 35822049
O-linked conjugation of ß-N-acetyl-glucosamine (O-GlcNAc) to serine and threonine residues is a post-translational modification process that senses nutrient availability and cellular stress and regulates diverse biological processes that are involved...
6.
Huynh V, Benavides G, Johnson M, Ouyang X, Chacko B, Osuma E, et al.
Mol Brain
. 2022 Mar;
15(1):22.
PMID: 35248135
The accumulation of neurotoxic proteins characteristic of age-related neurodegenerative pathologies such as Alzheimer's and Parkinson's diseases is associated with the perturbation of metabolism, bioenergetics, and mitochondrial quality control. One approach...
7.
Daneshgar N, Baguley A, Liang P, Wu F, Chu Y, Kinter M, et al.
Commun Biol
. 2021 Oct;
4(1):1200.
PMID: 34671066
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressively enlarging cysts. Here we elucidate the interplay between oxidative stress, mitochondrial dysfunction, and metabolic derangement using two mouse models of...
8.
Ouyang X, Becker Jr E, Bone N, Johnson M, Craver J, Zong W, et al.
Lab Invest
. 2021 Sep;
101(11):1467-1474.
PMID: 34504306
The mortality rates among patients who initially survive sepsis are, in part, associated with a high risk of secondary lung infections and respiratory failure. Given that phagolysosomes are important for...
9.
Rai G, Urban D, Mott B, Hu X, Yang S, Benavides G, et al.
J Med Chem
. 2020 Sep;
63(19):10984-11011.
PMID: 32902275
Lactate dehydrogenase (LDH) catalyzes the conversion of pyruvate to lactate, with concomitant oxidation of reduced nicotinamide adenine dinucleotide as the final step in the glycolytic pathway. Glycolysis plays an important...
10.
Ouyang X, Ahmad I, Johnson M, Redmann M, Craver J, Wani W, et al.
Lab Invest
. 2020 May;
100(9):1238-1251.
PMID: 32350405
The mechanisms which underlie defects in learning and memory are a major area of focus with the increasing incidence of Alzheimer's disease in the aging population. The complex genetically-controlled, age-,...