Michelle E Mulcahy
Overview
Explore the profile of Michelle E Mulcahy including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
340
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Recent Articles
1.
Vozza E, Mulcahy M, McLoughlin R
Front Immunol
. 2021 Jul;
12:667387.
PMID: 34220813
The success of as a human commensal and an opportunistic pathogen relies on its ability to adapt to several niches within the host. The innate immune response plays a key...
2.
Mulcahy M, OBrien E, OKeeffe K, Vozza E, Leddy N, McLoughlin R
Front Immunol
. 2020 Dec;
11:565545.
PMID: 33262756
Polymorphonuclear neutrophils (PMN) are critical for first line innate immune defence against . Mature circulating PMN maintain a short half-life ending in constitutive apoptotic cell death. This makes them unlikely...
3.
Musilova J, Mulcahy M, Kuijk M, McLoughlin R, Bowie A
J Biol Chem
. 2019 Sep;
294(45):17031-17042.
PMID: 31558608
Pathogen activation of innate immune pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs) stimulates cellular signaling pathways. This often leads to outcomes that contribute to pathogen clearance. Alternatively, activation...
4.
Lacey K, Mulcahy M, Towell A, Geoghegan J, McLoughlin R
PLoS Pathog
. 2019 Apr;
15(4):e1007713.
PMID: 31009507
Staphylococcus aureus expresses a number of cell wall-anchored proteins that mediate adhesion and invasion of host cells and tissues and promote immune evasion, consequently contributing to the virulence of this...
5.
Leech J, Lacey K, Mulcahy M, Medina E, McLoughlin R
J Immunol
. 2017 Feb;
198(6):2352-2365.
PMID: 28167629
IL-10 is a potent anti-inflammatory mediator that plays a crucial role in limiting host immunopathology during bacterial infections by controlling effector T cell activation. has previously been shown to manipulate...
6.
Mulcahy M, McLoughlin R
mBio
. 2016 Dec;
7(6).
PMID: 27965455
Nasal carriage of Staphylococcus aureus is a significant risk factor for secondary staphylococcal pneumonia in influenza A virus (IAV)-infected hosts. However, little research has been undertaken to define the environmental...
7.
Mulcahy M, McLoughlin R
Trends Microbiol
. 2016 Jul;
24(11):872-886.
PMID: 27474529
Staphylococcus aureus persistently colonizes the anterior nares of approximately one fifth of the population and nasal carriage is a significant risk factor for infection. Recent advances have significantly refined our...
8.
Maher B, Mulcahy M, Murphy A, Wilk M, OKeeffe K, Geoghegan J, et al.
Infect Immun
. 2013 Oct;
81(12):4478-89.
PMID: 24082072
Recent work has identified T cells and the cytokines they produce as important correlates of immune protection during Staphylococcus aureus infections through the ability of these T cells to regulate...
9.
Mulcahy M, Geoghegan J, Monk I, OKeeffe K, Walsh E, Foster T, et al.
PLoS Pathog
. 2013 Jan;
8(12):e1003092.
PMID: 23300445
Staphylococcus aureus asymptomatically colonises the anterior nares, but the host and bacterial factors that facilitate colonisation remain incompletely understood. The S. aureus surface protein ClfB has been shown to mediate...