Michele Zeinieh
Overview
Explore the profile of Michele Zeinieh including associated specialties, affiliations and a list of published articles.
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13
Citations
474
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Recent Articles
1.
Andrade A, Annett A, Karimi E, Topouza D, Rezanejad M, Liu Y, et al.
Nat Commun
. 2024 Sep;
15(1):7769.
PMID: 39237515
Histone H3-mutant gliomas are deadly brain tumors characterized by a dysregulated epigenome and stalled differentiation. In contrast to the extensive datasets available on tumor cells, limited information exists on their...
2.
Chen Y, Leibovitch M, Zeinieh M, Jabado N, Brodt P
Pharmaceuticals (Basel)
. 2023 Jun;
16(2).
PMID: 37259440
Pediatric high-grade gliomas (pHGG) accounts for approximately 8-12% of primary brain tumors in children. Prognosis is poor, with a median survival of 9-15 months. Insulin-like growth factor 1-receptor (IGF-1R) gene...
3.
Khazaei S, Chen C, Andrade A, Kabir N, Azarafshar P, Morcos S, et al.
Cell
. 2023 Mar;
186(6):1162-1178.e20.
PMID: 36931244
Germline histone H3.3 amino acid substitutions, including H3.3G34R/V, cause severe neurodevelopmental syndromes. To understand how these mutations impact brain development, we generated H3.3G34R/V/W knock-in mice and identified strikingly distinct developmental...
4.
Tawil N, Bassawon R, Meehan B, Nehme A, Montermini L, Gayden T, et al.
Blood Adv
. 2021 Mar;
5(6):1682-1694.
PMID: 33720339
Vascular anomalies, including local and peripheral thrombosis, are a hallmark of glioblastoma (GBM) and an aftermath of deregulation of the cancer cell genome and epigenome. Although the molecular effectors of...
5.
Chen C, Deshmukh S, Jessa S, Hadjadj D, Lisi V, Andrade A, et al.
Cell
. 2020 Dec;
183(6):1617-1633.e22.
PMID: 33259802
Histone H3.3 glycine 34 to arginine/valine (G34R/V) mutations drive deadly gliomas and show exquisite regional and temporal specificity, suggesting a developmental context permissive to their effects. Here we show that...
6.
Boileau M, Shirinian M, Gayden T, Harutyunyan A, Chen C, Mikael L, et al.
Nat Commun
. 2019 Jun;
10(1):2891.
PMID: 31253791
Our ability to manage acute myeloid leukemia (AML) is limited by our incomplete understanding of the epigenetic disruption central to leukemogenesis, including improper histone methylation. Here we examine 16 histone...
7.
Harutyunyan A, Krug B, Chen H, Papillon-Cavanagh S, Zeinieh M, De Jay N, et al.
Nat Commun
. 2019 Mar;
10(1):1262.
PMID: 30890717
Lys-27-Met mutations in histone 3 genes (H3K27M) characterize a subgroup of deadly gliomas and decrease genome-wide H3K27 trimethylation. Here we use primary H3K27M tumor lines and isogenic CRISPR-edited controls to...
8.
Rivera B, Gayden T, Carrot-Zhang J, Nadaf J, Boshari T, Faury D, et al.
Acta Neuropathol
. 2016 Feb;
131(6):847-63.
PMID: 26920151
Dysembryoplastic neuroepithelial tumor (DNET) is a benign brain tumor associated with intractable drug-resistant epilepsy. In order to identify underlying genetic alterations and molecular mechanisms, we examined three family members affected...
9.
Zeinieh M, Salehi A, Rajkumar V, Barker P
J Cell Sci
. 2014 Dec;
128(3):447-59.
PMID: 25472715
The p75 neurotrophin receptor (p75NTR, also known as tumor necrosis factor receptor superfamily member 16) is implicated in diverse cellular events, but fundamental aspects of its signaling mechanisms remain unclear....
10.
Forsyth P, Krishna N, Lawn S, Valadez J, Qu X, Fenstermacher D, et al.
J Biol Chem
. 2014 Feb;
289(12):8067-85.
PMID: 24519935
Malignant gliomas are highly invasive, proliferative, and resistant to treatment. Previously, we have shown that p75 neurotrophin receptor (p75NTR) is a novel mediator of invasion of human glioma cells. However,...