Carol C L Chen
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Explore the profile of Carol C L Chen including associated specialties, affiliations and a list of published articles.
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12
Citations
508
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Recent Articles
1.
Johnston M, Lee J, Hu B, Nikolic A, Hasheminasabgorji E, Baguette A, et al.
Cell
. 2024 Jul;
187(18):4926-4945.e22.
PMID: 38986619
Posterior fossa group A (PFA) ependymoma is a lethal brain cancer diagnosed in infants and young children. The lack of driver events in the PFA linear genome led us to...
2.
Andrade A, Chen C, Jabado N
Trends Cancer
. 2023 Mar;
9(5):444-455.
PMID: 36933956
Recurrent somatic mutations in histone 3 (H3) variants (termed 'oncohistones') have been identified in high-grade gliomas (HGGs) in children and young adults and induce tumorigenesis through disruption of chromatin states....
3.
Khazaei S, Chen C, Andrade A, Kabir N, Azarafshar P, Morcos S, et al.
Cell
. 2023 Mar;
186(6):1162-1178.e20.
PMID: 36931244
Germline histone H3.3 amino acid substitutions, including H3.3G34R/V, cause severe neurodevelopmental syndromes. To understand how these mutations impact brain development, we generated H3.3G34R/V/W knock-in mice and identified strikingly distinct developmental...
4.
Chen C, Andrade A, Jabado N
Mol Cell
. 2023 Jan;
83(2):163-164.
PMID: 36669477
To investigate epigenetic dependencies and identify therapeutic vulnerabilities, Mo et al. and Panditharatna et al. performed CRISPR screens and show that deadly H3K27M gliomas are dependent on mammalian BAF (SWI/SNF)...
5.
Chaouch A, Berlandi J, Chen C, Frey F, Badini S, Harutyunyan A, et al.
Mol Cell
. 2021 Nov;
81(23):4876-4890.e7.
PMID: 34739871
Histone H3.3 lysine-to-methionine substitutions K27M and K36M impair the deposition of opposing chromatin marks, H3K27me3/me2 and H3K36me3/me2. We show that these mutations induce hypotrophic and disorganized eyes in Drosophila eye...
6.
Chen C, Deshmukh S, Jessa S, Hadjadj D, Lisi V, Andrade A, et al.
Cell
. 2020 Dec;
183(6):1617-1633.e22.
PMID: 33259802
Histone H3.3 glycine 34 to arginine/valine (G34R/V) mutations drive deadly gliomas and show exquisite regional and temporal specificity, suggesting a developmental context permissive to their effects. Here we show that...
7.
Khazaei S, De Jay N, Deshmukh S, Hendrikse L, Jawhar W, Chen C, et al.
Cancer Discov
. 2020 Sep;
10(12):1968-1987.
PMID: 32967858
Glycine 34-to-tryptophan (G34W) substitutions in H3.3 arise in approximately 90% of giant cell tumor of bone (GCT). Here, we show H3.3 G34W is necessary for tumor formation. By profiling the...
8.
Krug B, De Jay N, Harutyunyan A, Deshmukh S, Marchione D, Guilhamon P, et al.
Cancer Cell
. 2019 Sep;
36(3):338-339.
PMID: 31526762
No abstract available.
9.
Boileau M, Shirinian M, Gayden T, Harutyunyan A, Chen C, Mikael L, et al.
Nat Commun
. 2019 Jun;
10(1):2891.
PMID: 31253791
Our ability to manage acute myeloid leukemia (AML) is limited by our incomplete understanding of the epigenetic disruption central to leukemogenesis, including improper histone methylation. Here we examine 16 histone...
10.
Krug B, De Jay N, Harutyunyan A, Deshmukh S, Marchione D, Guilhamon P, et al.
Cancer Cell
. 2019 May;
35(5):782-797.e8.
PMID: 31085178
High-grade gliomas defined by histone 3 K27M driver mutations exhibit global loss of H3K27 trimethylation and reciprocal gain of H3K27 acetylation, respectively shaping repressive and active chromatin landscapes. We generated...