Michela Traglia
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Explore the profile of Michela Traglia including associated specialties, affiliations and a list of published articles.
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65
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5540
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Recent Articles
1.
Ryu J, Yan Z, Montano M, Sozmen E, Dixit K, Suryawanshi R, et al.
Nature
. 2024 Aug;
633(8031):905-913.
PMID: 39198643
Life-threatening thrombotic events and neurological symptoms are prevalent in COVID-19 and are persistent in patients with long COVID experiencing post-acute sequelae of SARS-CoV-2 infection. Despite the clinical evidence, the underlying...
2.
Keaton J, Kamali Z, Xie T, Vaez A, Williams A, Goleva S, et al.
Nat Genet
. 2024 Apr;
56(5):778-791.
PMID: 38689001
Hypertension affects more than one billion people worldwide. Here we identify 113 novel loci, reporting a total of 2,103 independent genetic signals (P < 5 × 10) from the largest...
3.
Chen X, Haribowo A, Baik A, Fossati A, Stevenson E, Chen Y, et al.
Sci Adv
. 2023 Dec;
9(49):eadj4884.
PMID: 38064566
Oxygen deprivation and excess are both toxic. Thus, the body's ability to adapt to varying oxygen tensions is critical for survival. While the hypoxia transcriptional response has been well studied,...
4.
Nelson M, Liu P, Agrawal A, Yip O, Blumenfeld J, Traglia M, et al.
Nat Neurosci
. 2023 Nov;
26(12):2104-2121.
PMID: 37957317
Apolipoprotein E4 (APOE4) is the strongest genetic risk factor for late-onset Alzheimer's disease (LOAD), leading to earlier age of clinical onset and exacerbating pathologies. There is a critical need to...
5.
Koutsodendris N, Blumenfeld J, Agrawal A, Traglia M, Yip O, Rao A, et al.
Cell Rep
. 2023 Oct;
42(10):113252.
PMID: 37863057
Apolipoprotein E4 (APOE4) is an important driver of Tau pathology, gliosis, and degeneration in Alzheimer's disease (AD). Still, the mechanisms underlying these APOE4-driven pathological effects remain elusive. Here, we report...
6.
Koutsodendris N, Blumenfeld J, Agrawal A, Traglia M, Grone B, Zilberter M, et al.
Nat Aging
. 2023 Apr;
3(3):275-296.
PMID: 37118426
Apolipoprotein E4 (APOE4) is the strongest known genetic risk factor for late-onset Alzheimer's disease (AD). Conditions of stress or injury induce APOE expression within neurons, but the role of neuronal...
7.
Traglia M, Bout M, Weiss L
PLoS Genet
. 2022 May;
18(5):e1010147.
PMID: 35511767
Phenotypic differences across sexes are pervasive, but the genetic architecture of sex differences within and across phenotypes is mostly unknown. In this study, we aimed to improve detection power for...
8.
Ruth K, Day F, Hussain J, Martinez-Marchal A, Aiken C, Azad A, et al.
Nature
. 2021 Aug;
596(7872):393-397.
PMID: 34349265
Reproductive longevity is essential for fertility and influences healthy ageing in women, but insights into its underlying biological mechanisms and treatments to preserve it are limited. Here we identify 290...
9.
Lyall K, Ames J, Pearl M, Traglia M, Weiss L, Windham G, et al.
Mol Autism
. 2021 Mar;
12(1):24.
PMID: 33736683
Background: The Early Markers for Autism (EMA) study is a population-based case-control study designed to learn more about early biologic processes involved in ASD. Methods: Participants were drawn from Southern...
10.
Martin J, Khramtsova E, Goleva S, Blokland G, Traglia M, Walters R, et al.
Biol Psychiatry
. 2021 Mar;
89(12):1127-1137.
PMID: 33648717
Background: The origin of sex differences in prevalence and presentation of neuropsychiatric and behavioral traits is largely unknown. Given established genetic contributions and correlations, we tested for a sex-differentiated genetic...