Michel Guertin
Overview
Explore the profile of Michel Guertin including associated specialties, affiliations and a list of published articles.
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Articles
30
Citations
572
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Recent Articles
1.
Ascenzi P, Bolognesi M, Guertin M, Moens L
J Inorg Biochem
. 2023 Oct;
:112396.
PMID: 37838607
No abstract available.
2.
Vincent A, Bourbonnais Y, Brouard J, Deveau H, Droit A, Gagne S, et al.
Biochem Mol Biol Educ
. 2017 Sep;
46(1):31-38.
PMID: 28902453
A recent scientific discipline, bioinformatics, defined as using informatics for the study of biological problems, is now a requirement for the study of biological sciences. Bioinformatics has become such a...
3.
Carabet L, Guertin M, Lague P, Lamoureux G
J Phys Chem B
. 2017 Aug;
121(37):8706-8718.
PMID: 28835102
Many globins convert NO to innocuous NO through their nitric oxide dioxygenase (NOD) activity. Mycobacterium tuberculosis fights the oxidative and nitrosative stress imposed by its host (the toxic effects of...
4.
Pesce A, Bustamante J, Bidon-Chanal A, Boechi L, Estrin D, Luque F, et al.
FEBS J
. 2015 Oct;
283(2):305-22.
PMID: 26499089
Unlabelled: A unique defense mechanisms by which Mycobacterium tuberculosis protects itself from nitrosative stress is based on the O2 -dependent NO-dioxygenase (NOD) activity of truncated hemoglobin 2/2HbN (Mt2/2HbN). The NOD...
5.
Rheault J, Gagne E, Guertin M, Lamoureux G, Auger M, Lague P
Biochemistry
. 2015 Feb;
54(11):2073-84.
PMID: 25723781
A singular aspect of the 2-on-2 hemoglobin structures of groups I and II is the presence of tunnels linking the protein surface to the distal heme pocket, supporting the storage...
6.
Savard P, Daigle R, Morin S, Sebilo A, Meindre F, Lague P, et al.
Biochemistry
. 2011 Oct;
50(51):11121-30.
PMID: 21999759
The potent nitric oxide dioxygenase (NOD) activity (trHbN-Fe²⁺-O₂ + (•)NO → trHbN-Fe³⁺-OH₂ + NO₃⁻) of Mycobacterium tuberculosis truncated hemoglobin N (trHbN) protects aerobic respiration from inhibition by (•)NO. The high...
7.
Pesce A, Nardini M, Labarre M, Richard C, Wittenberg J, Wittenberg B, et al.
Biochim Biophys Acta
. 2010 Nov;
1814(6):810-6.
PMID: 21070893
Within the 2/2 hemoglobin sub-family, no group II 2/2Hbs from proteobacteria have been so far studied. Here we present the first structural characterization of a group II 2/2Hb from the...
8.
Daigle R, Rousseau J, Guertin M, Lague P
Biophys J
. 2009 Dec;
97(11):2967-77.
PMID: 19948126
Mycobacterium tuberculosis group I truncated hemoglobin trHbN catalyzes the oxidation of nitric oxide (NO) to nitrate with a second-order rate constant k approximately 745 microM(-1) s(-1) at 23 degrees C...
9.
Daigle R, Guertin M, Lague P
Proteins
. 2008 Nov;
75(3):735-47.
PMID: 19003999
The structure of oxygenated trHbN from Mycobacterium tuberculosis shows an extended heme distal hydrogen-bond network that includes Tyr33(B10), Gln58(E11), and the bound O(2). In addition, trHbN structure shows a network...
10.
Ouellet Y, Daigle R, Lague P, Dantsker D, Milani M, Bolognesi M, et al.
J Biol Chem
. 2008 Aug;
283(40):27270-8.
PMID: 18676995
The survival of Mycobacterium tuberculosis requires detoxification of host *NO. Oxygenated Mycobacterium tuberculosis truncated hemoglobin N catalyzes the rapid oxidation of nitric oxide to innocuous nitrate with a second-order rate...