Michael Zasloff
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Explore the profile of Michael Zasloff including associated specialties, affiliations and a list of published articles.
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6089
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Recent Articles
11.
Eekhoff E, de Ruiter R, Smilde B, Schoenmaker T, de Vries T, Netelenbos C, et al.
Hum Gene Ther
. 2022 May;
33(15-16):782-788.
PMID: 35502479
Fibrodysplasia ossificans progressiva (FOP) is a rare and devastating genetic disease, in which soft connective tissue is converted into heterotopic bone through an endochondral ossification process. Patients succumb early as...
12.
Kreiser R, Wright A, Sasser L, Rinauro D, Gabriel J, Hsu C, et al.
ACS Chem Neurosci
. 2022 Apr;
13(8):1219-1231.
PMID: 35404569
The molecular composition of the plasma membrane plays a key role in mediating the susceptibility of cells to perturbations induced by toxic molecules. The pharmacological regulation of the properties of...
13.
Alam M, Yang D, Li X, Liu J, Back T, Trivett A, et al.
Cell Rep
. 2022 Jan;
38(2):110090.
PMID: 35021075
Alpha-synuclein (αS) is causally involved in the development of Parkinson disease (PD); however, its role in normal vertebrate physiology has remained unknown. Recent studies demonstrate that αS is induced by...
14.
West C, McVey Neufeld K, Mao Y, Stanisz A, Forsythe P, Bienenstock J, et al.
Sci Rep
. 2021 Oct;
11(1):21130.
PMID: 34702901
The vagus nerve relays mood-altering signals originating in the gut lumen to the brain. In mice, an intact vagus is required to mediate the behavioural effects of both intraluminally applied...
15.
Limbocker R, Errico S, Barbut D, Knowles T, Vendruscolo M, Chiti F, et al.
Nat Prod Rep
. 2021 Oct;
39(4):742-753.
PMID: 34698757
Covering: 1993 to 2021 (mainly 2017-2021)Alzheimer's and Parkinson's diseases are neurodegenerative conditions affecting over 50 million people worldwide. Since these disorders are still largely intractable pharmacologically, discovering effective treatments is...
16.
Bosch T, Zasloff M
mBio
. 2021 Sep;
12(5):e0184721.
PMID: 34579574
Antimicrobial peptides (AMPs) are short and generally positively charged peptides found in a wide variety of life forms from microorganisms to humans. Their wide range of activity against pathogens, including...
17.
Errico S, Ramshini H, Capitini C, Canale C, Spaziano M, Barbut D, et al.
ACS Chem Neurosci
. 2021 Aug;
12(17):3189-3202.
PMID: 34382791
Many neurodegenerative diseases are associated with the self-assembly of peptides and proteins into fibrillar aggregates. Soluble misfolded oligomers formed during the aggregation process, or released by mature fibrils, play a...
18.
Hauser R, Sutherland D, Madrid J, Rol M, Frucht S, Isaacson S, et al.
Clin Park Relat Disord
. 2021 Jul;
1:2-7.
PMID: 34316590
Background: Parkinson's disease (PD) is associated with α-synuclein (αS) aggregation within the enteric nervous system (ENS) and constipation. Squalamine displaces proteins that are electrostatically bound to intracellular membranes and through...
19.
Limbocker R, Staats R, Chia S, Ruggeri F, Mannini B, Xu C, et al.
Front Neurosci
. 2021 Jul;
15:680026.
PMID: 34220435
The aberrant aggregation of proteins is a key molecular event in the development and progression of a wide range of neurodegenerative disorders. We have shown previously that squalamine and trodusquemine,...
20.
Perni M, van der Goot A, Limbocker R, van Ham T, Aprile F, Xu C, et al.
Front Cell Dev Biol
. 2021 Apr;
9:552549.
PMID: 33829010
The aggregation of α-synuclein is a hallmark of Parkinson's disease (PD) and a variety of related neurological disorders. A number of mutations in this protein, including A30P and A53T, are...