Michael W Mather
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Explore the profile of Michael W Mather including associated specialties, affiliations and a list of published articles.
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54
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3734
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Recent Articles
1.
Haile M, Shukla A, Zhen J, Mather M, Bhatnagar S, Zhang Z, et al.
bioRxiv
. 2025 Mar;
PMID: 40060536
The sodium efflux pump ATP4 is a leading antimalarial target, but suffers from a lack of high-resolution structural information needed to identify functionally important features in conserved regions and guide...
2.
Rachuri S, Nepal B, Shukla A, Ramanathan A, Morrisey J, Daly T, et al.
Proc Natl Acad Sci U S A
. 2025 Jan;
122(2):e2403689122.
PMID: 39773028
Among new antimalarials discovered over the past decade are multiple chemical scaffolds that target P-type ATPase (ATP4). This essential protein is a Na pump responsible for the maintenance of Na...
3.
Davies T, Peng X, Salem J, Elcioglu Z, Kremneva A, Gruber M, et al.
Clin Otolaryngol
. 2024 Oct;
50(1):1-14.
PMID: 39394875
Objectives: Acute otitis media (AOM) is a common childhood infection. Recurrent AOM affects a subset of children, resulting in an adverse impact on quality of life, socioeconomic disadvantage, and risk...
4.
Pou S, Winter R, Dodean R, Liebman K, Li Y, Mather M, et al.
ACS Infect Dis
. 2024 Jun;
10(7):2419-2442.
PMID: 38862127
ELQ-300 is a potent antimalarial drug with activity against blood, liver, and vector stages of the disease. A prodrug, , exhibits reduced crystallinity and improved in vivo efficacy in preclinical...
5.
Talks B, Mather M, Chahal M, Coates M, Clatworthy M, Haniffa M
Annu Rev Genomics Hum Genet
. 2024 Apr;
25(1):161-182.
PMID: 38594932
The development and deployment of single-cell genomic technologies have driven a resolution revolution in our understanding of the immune system, providing unprecedented insight into the diversity of immune cells present...
6.
Lamb I, Okoye I, Mather M, Vaidya A
Annu Rev Microbiol
. 2023 Jul;
77:541-560.
PMID: 37406344
Apicomplexan parasites constitute more than 6,000 species infecting a wide range of hosts. These include important pathogens such as those causing malaria and toxoplasmosis. Their evolutionary emergence coincided with the...
7.
Powell J, Powell S, Mather M, Beck L, Nelson A, Palmowski P, et al.
Thorax
. 2023 Feb;
78(10):1019-1027.
PMID: 36808087
Background: Tracheostomies in children are associated with significant morbidity, poor quality of life, excess healthcare costs and excess mortality. The underlying mechanisms facilitating adverse respiratory outcomes in tracheostomised children are...
8.
Mather M, Talks B, Dawe N, Powell J
Transl Pediatr
. 2022 Nov;
11(10):1739-1742.
PMID: 36345445
No abstract available.
9.
Dass S, Mather M, Morrisey J, Ling L, Vaidya A, Ke H
PLoS One
. 2022 Oct;
17(10):e0274993.
PMID: 36201550
The mitochondrion of malaria parasites is an attractive antimalarial drug target, which require mitoribosomes to translate genes encoded in the mitochondrial (mt) DNA. Plasmodium mitoribosomes are composed of highly fragmented...
10.
Lamb I, Rios K, Shukla A, Ahiya A, Morrisey J, Mell J, et al.
PLoS One
. 2022 Aug;
17(8):e0273357.
PMID: 35984838
Despite ongoing efforts to control malaria infection, progress in lowering the number of deaths and infections appears to have stalled. The continued high incidence of malaria infection and mortality is...