Michael W H Coughtrie
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Explore the profile of Michael W H Coughtrie including associated specialties, affiliations and a list of published articles.
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42
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810
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Recent Articles
1.
Doerksen M, Seo D, Smith A, Jones R, Coughtrie M, Collier A
Xenobiotica
. 2023 May;
53(4):223-230.
PMID: 37194558
Glutathione S-transferases (GSTs) are conjugating enzymes involved in drug metabolism, antioxidant defence, and cell signalling. Herein, we investigated hepatic GST conjugation in several mouse and rat strains, including both sexes,...
2.
Price H, Pang N, Kim H, Coughtrie M, Collier A
J Assist Reprod Genet
. 2022 Jan;
39(1):227-238.
PMID: 34988769
Purpose: Assisted reproduction technologies (ART) are associated with increased risks of pregnancy complications and obstetric interventions. Here, we aimed to determine if ART affects placental inflammation and oxidative stress as...
3.
Doerksen M, Jones R, Coughtrie M, Collier A
Eur J Drug Metab Pharmacokinet
. 2020 Dec;
46(2):173-183.
PMID: 33340340
Mathematical models that can predict the kinetics of compounds have been increasingly adopted for drug development and risk assessment. Data for these models may be generated from in vitro experimental...
4.
Price H, Lai D, Kim H, Wright T, Coughtrie M, Collier A
Toxicol Rep
. 2020 Oct;
7:1311-1318.
PMID: 33072523
Background: Nonsteroidal anti-inflammatory drugs are contraindicated in the third trimester of pregnancy due to negative effects including alteration of uteroplacental blood flow, premature ductus arteriosus closure, and adverse effects on...
5.
Smith A, Page B, Collier A, Coughtrie M
ACS Omega
. 2020 Apr;
5(12):6872-6887.
PMID: 32258923
The elimination of numerous endogenous compounds and xenobiotics via glucuronidation by uridine-5'-diphosphate glycosyltransferase enzymes (UGTs) is an essential process of the body's chemical defense system. UGTs have distinct but overlapping...
6.
Liu Y, Badee J, Takahashi R, Schmidt S, Parrott N, Fowler S, et al.
J Clin Pharmacol
. 2019 Dec;
60(6):722-733.
PMID: 31879975
Uridine diphosphate glucuronosyltransferases (UGTs) catalyze glucuronidation to facilitate systemic and local clearance of numerous chemicals and drugs. To investigate whether UGT expression is coregulated in human liver, we analyzed the...
7.
Walia G, Smith A, Riches Z, Collier A, Coughtrie M
Xenobiotica
. 2017 Sep;
48(9):882-890.
PMID: 28868965
1. The UDP-glucuronosyltransferase (UGT) enzymes are important in the metabolism, elimination and detoxification of many xenobiotics and endogenous compounds. As extrapolation of in vitro kinetics of drug metabolizing enzymes to...
8.
Liu Y, Coughtrie M
Pharmaceutics
. 2017 Sep;
9(3).
PMID: 28867809
Uridine diphosphate-glucuronosyltransferases (UGTs) are phase 2 conjugation enzymes mainly located in the endoplasmic reticulum (ER) of the liver and many other tissues, and can be recovered in artificial ER membrane...
9.
Coughtrie M
Chem Biol Interact
. 2016 May;
259(Pt A):2-7.
PMID: 27174136
The sulfuryl transfer reaction is of fundamental biological importance. One of the most important manifestations of this process are the reactions catalyzed by members of the cytosolic sulfotransferase (SULT) superfamily....
10.
Coughtrie M
Drug Metab Lett
. 2015 Jun;
9(2):99-108.
PMID: 26031463
Understanding the detailed ontogeny of xenobiotic metabolizing enzymes is important if we are to be able to predict the risk of toxicity to the developing fetus or the fate of...