Michael Thumm
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Explore the profile of Michael Thumm including associated specialties, affiliations and a list of published articles.
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9008
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Recent Articles
1.
Chen X, Tsvetkov A, Shen H, Isidoro C, Ktistakis N, Linkermann A, et al.
Autophagy
. 2024 Mar;
20(6):1213-1246.
PMID: 38442890
Macroautophagy/autophagy is a complex degradation process with a dual role in cell death that is influenced by the cell types that are involved and the stressors they are exposed to....
2.
3.
Marquardt L, Montino M, Muhe Y, Schlotterhose P, Thumm M
Cells
. 2023 Aug;
12(16).
PMID: 37626866
The putative phospholipase Atg15 is required for the intravacuolar lysis of autophagic bodies and MVB vesicles. Intracellular membrane lysis is a highly sophisticated mechanism that is not fully understood. The...
4.
Marquardt L, Thumm M
Biol Chem
. 2023 May;
404(8-9):813-819.
PMID: 37139661
Atg18, Atg21 and Hsv2 are homologous β-propeller proteins binding to PI3P and PI(3,5)P. Atg18 is thought to organize lipid transferring protein complexes at contact sites of the growing autophagosome (phagophore)...
5.
Marquardt L, Taylor M, Kramer F, Schmitt K, Braus G, Valerius O, et al.
Autophagy
. 2022 May;
19(1):278-295.
PMID: 35574911
The yeast PROPPIN Atg18 folds as a β-propeller with two binding sites for phosphatidylinositol-3-phosphate (PtdIns3P) and PtdIns(3,5)P at its circumference. Membrane insertion of an amphipathic loop of Atg18 leads to...
6.
Klionsky D, Abdel-Aziz A, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, et al.
Autophagy
. 2021 Feb;
17(1):1-382.
PMID: 33634751
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our...
7.
Bo Otto F, Thumm M
Int J Mol Sci
. 2020 Jul;
21(12).
PMID: 32599961
Nucleophagy, the selective subtype of autophagy that targets nuclear material for autophagic degradation, was not only shown to be a model system for the study of selective macroautophagy, but also...
8.
Munzel L, Neumann P, Otto F, Krick R, Metje-Sprink J, Kroppen B, et al.
Autophagy
. 2020 Jun;
17(6):1458-1478.
PMID: 32515645
Coupling of Atg8 to phosphatidylethanolamine is crucial for the expansion of the crescent-shaped phagophore during cargo engulfment. Atg21, a PtdIns3P-binding beta-propeller protein, scaffolds Atg8 and its E3-like complex Atg12-Atg5-Atg16 during...
9.
Otto F, Thumm M
Autophagy
. 2020 Feb;
17(3):626-639.
PMID: 32046569
Nucleophagy, the mechanism for autophagic degradation of nuclear material, occurs in both a macro- and micronucleophagic manner. Upon nitrogen deprivation, we observed, in an in-depth fluorescence microscopy study, the formation...
10.
Callegari S, Oeljeklaus S, Warscheid B, Dennerlein S, Thumm M, Rehling P, et al.
Autophagy
. 2016 Nov;
13(1):201-211.
PMID: 27846363
The E3 ubiquitin ligase PARK2 and the mitochondrial protein kinase PINK1 are required for the initiation of mitochondrial damage-induced mitophagy. Together, PARK2 and PINK1 generate a phospho-ubiquitin signal on outer...