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Michael Thorpe

Explore the profile of Michael Thorpe including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 42
Citations 696
Followers 0
Related Specialties
Biochemistry
General Medicine
Molecular Biology
Top 10 Co-Authors
Lars Hellman
Srinivas Akula
Zhirong Fu
Jukka Kervinen
Lawrence de Garavilla
Gurdeep Chahal
Gunnar Pejler
Vamsi Boinapally
Maike Gallwitz
Magnus Abrink
Published In
PLoS One
Int J Mol Sci
Biol Chem
Int Immunol
Front Plant Sci
Affiliations
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Recent Articles
21.
Asp-ase Activity of the Opossum Granzyme B Supports the Role of Granzyme B as Part of Anti-Viral Immunity Already during Early Mammalian Evolution
Fu Z, Thorpe M, Akula S, Hellman L
PLoS One . 2016 May; 11(5):e0154886. PMID: 27152961
Granzyme B is one of the key effector molecules in our defense against viruses and intracellular bacteria. This serine protease together with the pore forming protein perforin, induces caspase or...
22.
Correction: Granule Associated Serine Proteases of Hematopoietic Cells - An Analysis of Their Appearance and Diversification during Vertebrate Evolution
Akula S, Thorpe M, Boinapally V, Hellman L
PLoS One . 2015 Dec; 10(12):e0145592. PMID: 26694954
No abstract available.
23.
Granule Associated Serine Proteases of Hematopoietic Cells - An Analysis of Their Appearance and Diversification during Vertebrate Evolution
Akula S, Thorpe M, Boinapally V, Hellman L
PLoS One . 2015 Nov; 10(11):e0143091. PMID: 26569620
Serine proteases are among the most abundant granule constituents of several hematopoietic cell lineages including mast cells, neutrophils, cytotoxic T cells and NK cells. These proteases are stored in their...
24.
rMCP-2, the Major Rat Mucosal Mast Cell Protease, an Analysis of Its Extended Cleavage Specificity and Its Potential Role in Regulating Intestinal Permeability by the Cleavage of Cell Adhesion and Junction Proteins
Fu Z, Thorpe M, Hellman L
PLoS One . 2015 Jun; 10(6):e0131720. PMID: 26114959
Mast cells of the rat intestinal mucosa express three chymotryptic enzymes named rMCP-2, -3 and 4. rMCP-2, the most abundant of these enzymes, has been shown to increase the permeability...
25.
The Importance of Exosite Interactions for Substrate Cleavage by Human Thrombin
Chahal G, Thorpe M, Hellman L
PLoS One . 2015 Jun; 10(6):e0129511. PMID: 26110612
Thrombin is a serine protease of the chymotrypsin family that acts both as a procoagulant and as an anticoagulant by cleaving either factor VIII, factor V and fibrinogen or protein...
26.
Agomelatine-associated manic switch in bipolar depression: a case report
Thorpe M, Pannell J, Nance M
Aust N Z J Psychiatry . 2014 Mar; 48(10):958-9. PMID: 24658295
No abstract available.
27.
Hydrodynamics of steady state phloem transport with radial leakage of solute
Cabrita P, Thorpe M, Huber G
Front Plant Sci . 2014 Jan; 4:531. PMID: 24409189
Long-distance phloem transport occurs under a pressure gradient generated by the osmotic exchange of water associated with solute exchange in source and sink regions. But these exchanges also occur along...
28.
Duck hepatitis B virus covalently closed circular DNA appears to survive hepatocyte mitosis in the growing liver
Reaiche-Miller G, Thorpe M, Low H, Qiao Q, Scougall C, Mason W, et al.
Virology . 2013 Oct; 446(1-2):357-64. PMID: 24074600
Nucleos(t)ide analogues that inhibit hepatitis B virus (HBV) DNA replication are typically used as monotherapy for chronically infected patients. Treatment with a nucleos(t)ide analogue eliminates most HBV DNA replication intermediates...
29.
Granule proteases of hematopoietic cells, a family of versatile inflammatory mediators - an update on their cleavage specificity, in vivo substrates, and evolution
Hellman L, Thorpe M
Biol Chem . 2013 Aug; 395(1):15-49. PMID: 23969467
Cells from several of the hematopoietic cell lineages including mast cells, basophils, neutrophils, cytotoxic T cells, and natural killer (NK) cells store proteases at very high levels within their cytoplasmic...
30.
Mutations in Arg143 and Lys192 of the Human Mast Cell Chymase Markedly Affect the Activity of Five Potent Human Chymase Inhibitors
Ahooghalandari P, Hanke N, Thorpe M, Witte A, Messinger J, Hellman L
PLoS One . 2013 Jul; 8(6):e65988. PMID: 23840386
Chymotrypsin-like serine proteases are found in high abundance in mast cell granules. By site-directed mutatgenesis, we have previously shown that basic amino acids in positions 143 and 192 (Arg and...