Michael Thorpe
Overview
Explore the profile of Michael Thorpe including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
42
Citations
696
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
11.
Fu Z, Akula S, Thorpe M, Hellman L
Int J Mol Sci
. 2020 Jan;
21(1).
PMID: 31906570
Mast cells (MCs) are inflammatory cells primarily found in tissues in close contact with the external environment, such as the skin and the intestinal mucosa. They store large amounts of...
12.
Zhongwei Y, Akula S, Fu Z, de Garavilla L, Kervinen J, Thorpe M, et al.
Int J Mol Sci
. 2020 Jan;
20(24).
PMID: 31888202
Serine proteases constitute the major protein content of mast cell (MC) secretory granules. These proteases can generally be subdivided into chymases and tryptases based on their primary cleavage specificity. Here,...
13.
Fu Z, Akula S, Thorpe M, Hellman L
Int J Mol Sci
. 2019 Oct;
20(20).
PMID: 31627390
Mast cells (MC) are resident tissue cells found primarily at the interphase between tissues and the environment. These evolutionary old cells store large amounts of proteases within cytoplasmic granules, and...
14.
Thorpe M, Fu Z, Albat E, Akula S, de Garavilla L, Kervinen J, et al.
PLoS One
. 2018 Dec;
13(12):e0207826.
PMID: 30521603
Serine proteases constitute the major protein content of mast cell secretory granules. Here we present the extended cleavage specificity of two such proteases from the golden hamster, Mesocricetus auratus. Analysis...
15.
Fu Z, Akula S, Thorpe M, Chahal G, de Garavilla L, Kervinen J, et al.
Dev Comp Immunol
. 2018 Nov;
92:160-169.
PMID: 30481523
Serine proteases constitute the major protein content of mammalian mast cell granules and the selectivity for substrates by these proteases is of major importance for the role of mast cells...
16.
Fu Z, Thorpe M, Akula S, Chahal G, Hellman L
Front Immunol
. 2018 Nov;
9:2387.
PMID: 30459762
Serine proteases are major granule constituents of several of the human hematopoietic cell lineages. Four proteolytically active such proteases have been identified in human neutrophils: cathepsin G (hCG), N-elastase (hNE),...
17.
Thorpe M, Fu Z, Chahal G, Akula S, Kervinen J, de Garavilla L, et al.
PLoS One
. 2018 Apr;
13(4):e0195077.
PMID: 29652924
Human neutrophils express at least four active serine proteases, cathepsin G, N-elastase, proteinase 3 and neutrophil serine protease 4 (NSP4). They have all been extensively studied due to their importance...
18.
Hellman L, Akula S, Thorpe M, Fu Z
Front Immunol
. 2018 Jan;
8:1749.
PMID: 29312297
In most industrialized countries, allergies have increased in frequency quite dramatically during the past 50 years. Estimates show that 20-30% of the populations are affected. Allergies have thereby become one...
19.
Fu Z, Thorpe M, Alemayehu R, Roy A, Kervinen J, de Garavilla L, et al.
J Immunol
. 2017 Jan;
198(4):1474-1483.
PMID: 28053237
Human mast cell chymase (HC) and human neutrophil cathepsin G (hCG) show relatively similar cleavage specificities: they both have chymotryptic activity but can also cleave efficiently after leucine. Their relatively...
20.
Thorpe M, Akula S, Hellman L
Dev Comp Immunol
. 2016 May;
63:84-95.
PMID: 27216028
Here we present the extended cleavage specificity of catfish granzyme-like I, previously identified in fish NK-like cells. This protease has been characterised using substrate phage display and further validated by...