Michael T Morgan
Overview
Explore the profile of Michael T Morgan including associated specialties, affiliations and a list of published articles.
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14
Citations
546
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Recent Articles
1.
Basu A, Bobrovnikov D, Qureshi Z, Kayikcioglu T, Ngo T, Ranjan A, et al.
Nature
. 2020 Dec;
589(7842):462-467.
PMID: 33328628
Mechanical deformations of DNA such as bending are ubiquitous and have been implicated in diverse cellular functions. However, the lack of high-throughput tools to measure the mechanical properties of DNA...
2.
Nune M, Morgan M, Connell Z, McCullough L, Jbara M, Sun H, et al.
Elife
. 2019 Jan;
8.
PMID: 30681413
Monoubiquitination of histone H2B (H2B-Ub) plays a role in transcription and DNA replication, and is required for normal localization of the histone chaperone, FACT. In yeast, H2B-Ub is deubiquitinated by...
3.
Morgan M, Wolberger C
Methods Mol Biol
. 2018 Sep;
1844:59-70.
PMID: 30242703
Assays of the affinity of a deubiquitinating enzyme for substrate, either through binding studies or determination of the Michaelis constant, K, can shed light on substrate selectivity and the effects...
4.
Morrow M, Morgan M, Clerici M, Growkova K, Yan M, Komander D, et al.
EMBO Rep
. 2018 Aug;
19(10).
PMID: 30150323
A common strategy for exploring the biological roles of deubiquitinating enzymes (DUBs) in different pathways is to study the effects of replacing the wild-type DUB with a catalytically inactive mutant...
5.
Bhat S, Hwang Y, Gibson M, Morgan M, Taverna S, Zhao Y, et al.
J Am Chem Soc
. 2018 Jul;
140(30):9478-9485.
PMID: 29991262
A range of acyl-lysine (acyl-Lys) modifications on histones and other proteins have been mapped over the past decade but for most, their functional and structural significance remains poorly characterized. One...
6.
Morgan M, Wolberger C
Curr Opin Struct Biol
. 2016 Dec;
42:75-82.
PMID: 27923209
Histone ubiquitination plays a non-degradative role in regulating transcription and the DNA damage response. A mechanistic understanding of this chromatin modification has lagged that of small histone modifications because of...
7.
Morgan M, Haj-Yahya M, Ringel A, Bandi P, Brik A, Wolberger C
Science
. 2016 Feb;
351(6274):725-8.
PMID: 26912860
Monoubiquitinated histone H2B plays multiple roles in transcription activation. H2B is deubiquitinated by the Spt-Ada-Gcn5 acetyltransferase (SAGA) coactivator, which contains a four-protein subcomplex known as the deubiquitinating (DUB) module. The...
8.
Friscia L, Morgan M, Sparto P, Furman J, Whitney S
Otol Neurotol
. 2014 May;
35(5):884-8.
PMID: 24829039
Objective: The responsiveness (sensitivity to change) of many self-report measures commonly used with individuals who have balance and vestibular dysfunction has not been assessed. The purpose of this study was...
9.
Morgan M, Friscia L, Whitney S, Furman J, Sparto P
Otol Neurotol
. 2013 Apr;
34(6):1104-8.
PMID: 23542134
Hypothesis: The purpose of this research is to establish the test-retest reliability and convergent validity of the Falls Efficacy Scale-International (FES-I) in people with vestibular disorders. Background: Individuals with vestibular...
10.
Morgan M, Maiti A, Fitzgerald M, Drohat A
Nucleic Acids Res
. 2010 Nov;
39(6):2319-29.
PMID: 21097883
Deamination of 5-methylcytosine to thymine creates mutagenic G · T mispairs, contributing to cancer and genetic disease. Thymine DNA glycosylase (TDG) removes thymine from these G · T lesions, and...