Michael S VanNieuwenhze
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Explore the profile of Michael S VanNieuwenhze including associated specialties, affiliations and a list of published articles.
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2770
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Recent Articles
1.
Synthesis of the -Amino Acid Labionin through a Contrasteric Aziridination and Ring-Opening Sequence
Murphy B, Lin S, VanNieuwenhze M
Org Lett
. 2025 Feb;
27(7):1696-1699.
PMID: 39929605
The non-proteinogenic -amino acid labionin was discovered in 2010 and since has been described in many natural products, defining an entire family of lanthipeptides. The unusual amino acid is biosynthetically...
2.
Walenkiewicz B, VanNieuwenhze M
ACS Chem Biol
. 2024 Dec;
20(1):162-171.
PMID: 39668630
The threat of multidrug-resistant bacteria has been increasing steadily in the past century, posing a major health risk (Organización Mundial de la Salud. Directrices Sobre Componentes Básicos Para Los Programas...
3.
Delaby M, Yang L, Jacq M, Gallagher K, Kysela D, Hughes V, et al.
bioRxiv
. 2024 Nov;
PMID: 39574579
Cell elongation is a fundamental component of the bacterial cell cycle and has been studied over many decades, in part owing to its mechanisms being a target of numerous antibiotic...
4.
Gordhan B, Padarath K, Sewcharran A, McIvor A, VanNieuwenhze M, Waja Z, et al.
Pathogens
. 2024 Apr;
13(4).
PMID: 38668273
Growing evidence points to the presence of differentially culturable tubercle bacteria (DCTB) in clinical specimens from individuals with active tuberculosis (TB) disease. These bacteria are unable to grow on solid...
5.
Shaku M, Ocius K, Apostolos A, Pires M, VanNieuwenhze M, Dhar N, et al.
Front Cell Infect Microbiol
. 2023 Sep;
13:1205829.
PMID: 37692163
Introduction: Mycobacteria assemble a complex cell wall with cross-linked peptidoglycan (PG) which plays an essential role in maintenance of cell wall integrity and tolerance to osmotic pressure. We previously demonstrated...
6.
Bosquez-Berger T, Gudorf J, Kuntz C, Desmond J, Schlebach J, VanNieuwenhze M, et al.
J Med Chem
. 2023 Jul;
66(14):9466-9494.
PMID: 37437224
The US faces an unprecedented surge in fatal drug overdoses. Naloxone, the only antidote for opiate overdose, competes at the mu opioid receptor (μOR) orthosteric site. Naloxone struggles against fentanyl-class...
7.
Choo P, Wang C, VanNieuwenhze M, Kline K
Mol Microbiol
. 2022 Nov;
119(1):1-18.
PMID: 36420961
Enterococcus faecalis virulence requires cell wall-associated proteins, including the sortase-assembled endocarditis and biofilm associated pilus (Ebp), important for biofilm formation in vitro and in vivo. The current paradigm for sortase-assembled...
8.
Hirt H, Greenwood-Quaintance K, Barnes A, Karau M, Till L, Palzer E, et al.
Nat Commun
. 2022 Mar;
13(1):1377.
PMID: 35296679
Microbial communities provide protection to their hosts by resisting pathogenic invasion. Microbial residents of a host often exclude subsequent colonizers, but this protection is not well understood. The Enterococcus faecalis...
9.
Nakamoto R, Kwan J, Chin J, Ong H, Flores-Kim J, Midonet C, et al.
Proc Natl Acad Sci U S A
. 2021 Nov;
118(45).
PMID: 34732571
Many pathogenic bacteria are encased in a layer of capsular polysaccharide (CPS). This layer is important for virulence by masking surface antigens, preventing opsonophagocytosis, and avoiding mucus entrapment. The bacterial...
10.
Williams M, Aliashkevich A, Krol E, Kuru E, Bouchier J, Rittichier J, et al.
mBio
. 2021 Sep;
12(5):e0234621.
PMID: 34544272
Members of the are polarly growing bacteria that lack homologs of the canonical Rod complex. To investigate the mechanisms underlying polar cell wall synthesis, we systematically probed the function of...