Michael S Kapiloff
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Explore the profile of Michael S Kapiloff including associated specialties, affiliations and a list of published articles.
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61
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1526
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Recent Articles
1.
Zhu Y, Nair R, Xia X, Nahmou M, Li X, Yan W, et al.
Exp Eye Res
. 2024 Aug;
246:110017.
PMID: 39097072
Loss of retinal ganglion cells (RGCs) is central to the pathogenesis of optic neuropathies such as glaucoma. Increased RGC cAMP signaling is neuroprotective. We have shown that displacement of the...
2.
Li X, Li J, Samuelsson A, Thakur H, Kapiloff M
Mol Ther Methods Clin Dev
. 2024 Apr;
32(2):101233.
PMID: 38572067
Familial dilated cardiomyopathy is a prevalent cause of heart failure that results from the mutation of genes encoding proteins of diverse function. Despite modern therapy, dilated cardiomyopathy typically has a...
3.
Xia X, Shi C, Tsien C, Sun C, Xie L, Luo Z, et al.
eNeuro
. 2024 Mar;
11(3).
PMID: 38548335
Neuroprotection after injury or in neurodegenerative disease remains a major goal for basic and translational neuroscience. Retinal ganglion cells (RGCs), the projection neurons of the eye, degenerate in optic neuropathies...
4.
Cameron E, Nahmou M, Toth A, Heo L, Tanasa B, Dalal R, et al.
Nature
. 2023 Dec;
626(7999):574-582.
PMID: 38086421
The intrinsic mechanisms that regulate neurotoxic versus neuroprotective astrocyte phenotypes and their effects on central nervous system degeneration and repair remain poorly understood. Here we show that injured white matter...
5.
Zhu Y, Garcia-Sanchez J, Dalal R, Sun Y, Kapiloff M, Goldberg J, et al.
Exp Eye Res
. 2023 Oct;
236:109675.
PMID: 37820892
PIEZO1 and PIEZO2 are mechanosensitive ion channels that regulate many important physiological processes including vascular blood flow, touch, and proprioception. As the eye is subject to mechanical stress and is...
6.
Segal L, Etzion S, Elyagon S, Shahar M, Klapper-Goldstein H, Levitas A, et al.
Int J Mol Sci
. 2022 Sep;
23(17).
PMID: 36077014
Dedicator of cytokinesis 10 (Dock10) is a guanine nucleotide exchange factor for Cdc42 and Rac1 that regulates the JNK (c-Jun N-terminal kinase) and p38 MAPK (mitogen-activated protein kinase) signaling cascades....
7.
Turcotte M, Thakur H, Kapiloff M, Dodge-Kafka K
J Mol Cell Cardiol
. 2022 Aug;
172:26-40.
PMID: 35952391
The pleiotropic Ca/calmodulin-dependent phosphatase calcineurin is a key regulator of pathological cardiac myocyte hypertrophy. The selective activation of hypertrophic calcineurin signaling under stress conditions has been attributed to compartmentation of...
8.
Li J, Kelly S, Ivey J, Thorne P, Yamada K, Aikawa T, et al.
Physiol Genomics
. 2022 Jun;
54(7):261-272.
PMID: 35648460
Limited reports exist regarding adeno-associated virus (AAV) biodistribution in swine. This study assessed biodistribution following antegrade intracoronary and intravenous delivery of two self-complementary serotype 9 AAV (AAV9sc) biologics designed to...
9.
Yanucil C, Kentrup D, Li X, Grabner A, Schramm K, Martinez E, et al.
Sci Rep
. 2022 May;
12(1):7326.
PMID: 35513431
Fibroblast growth factor (FGF) 21, a hormone that increases insulin sensitivity, has shown promise as a therapeutic agent to improve metabolic dysregulation. Here we report that FGF21 directly targets cardiac...
10.
Yanucil C, Kentrup D, Campos I, Czaya B, Heitman K, Westbrook D, et al.
Kidney Int
. 2022 May;
102(2):261-279.
PMID: 35513125
Fibroblast growth factor (FGF) 23 is a phosphate-regulating hormone that is elevated in patients with chronic kidney disease and associated with cardiovascular mortality. Experimental studies showed that elevated FGF23 levels...