Michael S Bobola
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Explore the profile of Michael S Bobola including associated specialties, affiliations and a list of published articles.
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15
Citations
422
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Recent Articles
1.
Bobola M, Chen L, Ezeokeke C, Kuznetsova K, Lahti A, Lou W, et al.
Curr Pain Headache Rep
. 2018 Jul;
22(9):60.
PMID: 29987680
Ultrasound plays a significant role in the diagnosis and treatment of pain, with significant literature reaching back many years, especially with regard to diagnostic ultrasound and its use for guiding...
2.
Bobola M, Alnoor M, Chen J, Kolstoe D, Silbergeld D, Rostomily R, et al.
BBA Clin
. 2015 Jan;
3:1-10.
PMID: 25558448
Background: CpG methylation in the O-methylguanine-DNA methyltransferase (MGMT) promoter is associated with better outcome following alkylating agent chemotherapy in glioblastoma (GBM) and anaplastic glioma (AG). To what extent improved response...
3.
Iyer P, Srinivasan A, Singh S, Mascara G, Zayitova S, Sidone B, et al.
Chem Res Toxicol
. 2012 Dec;
26(1):156-68.
PMID: 23234400
Derivatives of methyl 3-(1-methyl-5-(1-methyl-5-(propylcarbamoyl)-1H-pyrrol-3-ylcarbamoyl)-1H-pyrrol-3-ylamino)-3-oxopropane-1-sulfonate (1), a peptide-based DNA minor groove binding methylating agent, were synthesized and characterized. In all cases, the N-terminus was appended with an O-methyl sulfonate ester, while...
4.
Bobola M, Kolstoe D, Blank A, Chamberlain M, Silber J
Front Oncol
. 2012 Dec;
2:176.
PMID: 23230562
Alkylating agents have long played a central role in the adjuvant therapy of glioblastoma (GBM). More recently, inclusion of temozolomide (TMZ), an orally administered methylating agent with low systemic toxicity,...
5.
Silber J, Bobola M, Blank A, Chamberlain M
Biochim Biophys Acta
. 2012 Jan;
1826(1):71-82.
PMID: 22244911
Gliomas are the most frequent adult primary brain tumor, and are invariably fatal. The most common diagnosis glioblastoma multiforme (GBM) afflicts 12,500 new patients in the U.S. annually, and has...
6.
Bobola M, Jankowski P, Gross M, Schwartz J, Finn L, Blank A, et al.
Int J Cancer
. 2011 Jan;
129(10):2370-9.
PMID: 21207372
Apurinic/apyrimidinic endonuclease (Ap endo) is a key DNA repair activity that confers radiation resistance in human cells. Here we examined the association between Ap endo activity and response to radiotherapy...
7.
Bobola M, Kolstoe D, Blank A, Silber J
Mol Cancer Ther
. 2010 May;
9(5):1208-18.
PMID: 20457618
Concurrent treatment with the methylating agent temozolomide during radiotherapy has yielded the first significant improvement in the survival of adult glioblastomas (GBM) in the last three decades. However, improved survival...
8.
Valera E, de Freitas Cortez M, Queiroz R, de Oliveira F, Brassesco M, Jabado N, et al.
Childs Nerv Syst
. 2008 Oct;
25(1):39-45.
PMID: 18946672
Background: Resistance to drug is a major cause of treatment failure in pediatric brain cancer. The multidrug resistance (MDR) phenotype can be mediated by the superfamily of adenosine triphosphate-binding cassette...
9.
Bobola M, Blank A, Berger M, Silber J
DNA Repair (Amst)
. 2007 May;
6(8):1127-33.
PMID: 17500046
The DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) is a cardinal defense against the mutagenic and carcinogenic effects of alkylating agents. We have reported evidence that absence of detectable MGMT activity...
10.
Bobola M, Varadarajan S, Smith N, Goff R, Kolstoe D, Blank A, et al.
Clin Cancer Res
. 2007 Jan;
13(2 Pt 1):612-20.
PMID: 17255284
Purpose: Defining the cytotoxicity of individual adducts in DNA is necessary for mechanistic understanding of human brain tumor resistance to therapeutic alkylating agents and for design of DNA repair-related antiresistance...