Michael S Bobola
Overview
Explore the profile of Michael S Bobola including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
422
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0
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Recent Articles
11.
Bobola M, Finn L, Ellenbogen R, Geyer J, Berger M, Braga J, et al.
Clin Cancer Res
. 2005 Oct;
11(20):7405-14.
PMID: 16243814
Purpose: Apurinic/apyrimidinic endonuclease (Ap endo) is a key DNA repair activity that confers resistance to radiation- and alkylator-induced cytotoxic abasic sites in human cells. We assayed apurinic/apyrimidinic endonuclease activity in...
12.
Bobola M, Silber J, Ellenbogen R, Geyer J, Blank A, Goff R
Clin Cancer Res
. 2005 Apr;
11(7):2747-55.
PMID: 15814657
Purpose: Primary brain tumors are the leading cause of cancer death in children. Our purpose is (a) to assess the contribution of the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) to...
13.
Bobola M, Emond M, Blank A, Meade E, Kolstoe D, Berger M, et al.
Clin Cancer Res
. 2004 Dec;
10(23):7875-83.
PMID: 15585620
Purpose: Apurinic/apyrimidinic endonuclease (Ap endo) is a key DNA repair enzyme that cleaves DNA at cytotoxic abasic sites caused by alkylating agents and radiation. We have observed that human glioma...
14.
Blank A, Bobola M, Gold B, Varadarajan S, Kolstoe D, Meade E, et al.
DNA Repair (Amst)
. 2004 May;
3(6):629-38.
PMID: 15135730
The Werner syndrome (WS) protein (WRN), a DNA helicase/exonuclease, is required for genomic stability and avoidance of cancer. Current evidence suggests that WRN is involved in the resolution of stalled...
15.
Silber J, Bobola M, Blank A, Schoeler K, Haroldson P, Huynh M, et al.
Clin Cancer Res
. 2002 Sep;
8(9):3008-18.
PMID: 12231548
Alkylating agents are standard components of adjuvant chemotherapy for gliomas. We provide evidence here that Ape1/Ref-1, the major mammalian apurinic/apyrimidinic endonuclease (Ap endo), contributes to alkylating agent resistance in human...