Michael Ritt
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Explore the profile of Michael Ritt including associated specialties, affiliations and a list of published articles.
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20
Citations
285
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Recent Articles
1.
Sadler F, Ma N, Ritt M, Sharma Y, Vaidehi N, Sivaramakrishnan S
Nature
. 2023 Mar;
615(7953):734-741.
PMID: 36890236
The third intracellular loop (ICL3) of the G protein-coupled receptor (GPCR) fold is important for the signal transduction process downstream of receptor activation. Despite this, the lack of a defined...
2.
Rai A, Shrivastava R, Vang D, Ritt M, Sadler F, Bhaban S, et al.
J Biol Chem
. 2022 Feb;
298(3):101688.
PMID: 35143838
A range of cargo adaptor proteins are known to recruit cytoskeletal motors to distinct subcellular compartments. However, the structural impact of cargo recruitment on motor function is poorly understood. Here,...
3.
Kim K, Paulekas S, Sadler F, Gupte T, Ritt M, Dysthe M, et al.
Proc Natl Acad Sci U S A
. 2021 Apr;
118(11).
PMID: 33836582
Classical pharmacological models have incorporated an "intrinsic efficacy" parameter to capture system-independent effects of G protein-coupled receptor (GPCR) ligands. However, the nonlinear serial amplification of downstream signaling limits quantitation of...
4.
Patel N, Siva M, Kumari R, Shewale D, Rai A, Ritt M, et al.
Sci Adv
. 2021 Feb;
7(6).
PMID: 33536208
Endocytic recycling is a complex itinerary, critical for many cellular processes. Membrane tubulation is a hallmark of recycling endosomes (REs), mediated by KIF13A, a kinesin-3 family motor. Understanding the regulatory...
5.
Lippert L, Ma N, Ritt M, Jain A, Vaidehi N, Sivaramakrishnan S
J Biol Chem
. 2021 Jan;
296:100339.
PMID: 33508318
The eukaryotic kinase domain has multiple intrinsically disordered regions whose conformation dictates kinase activity. Small molecule kinase inhibitors (SMKIs) rely on disrupting the active conformations of these disordered regions to...
6.
Gupte T, Ritt M, Sivaramakrishnan S
Methods Enzymol
. 2021 Jan;
647:173-208.
PMID: 33482988
ER/K α-helices are a subset of single alpha helical domains, which exhibit unusual stability as isolated protein secondary structures. They adopt an elongated structural conformation, while regulating the frequency of...
7.
Rai A, Vang D, Ritt M, Sivaramakrishnan S
J Biol Chem
. 2020 Dec;
296:100232.
PMID: 33372034
Myosin VI ensembles on endocytic cargo facilitate directed transport through a dense cortical actin network. Myosin VI is recruited to clathrin-coated endosomes via the cargo adaptor Dab2. Canonically, it has...
8.
Gupte T, Ritt M, Dysthe M, Malik R, Sivaramakrishnan S
Nat Commun
. 2019 Oct;
10(1):4836.
PMID: 31645561
Despite the crowded nature of the cellular milieu, ligand-GPCR-G protein interactions are traditionally viewed as spatially and temporally isolated events. In contrast, recent reports suggest the spatial and temporal coupling...
9.
Ritt M, Sivaramakrishnan S
Traffic
. 2018 Jun;
PMID: 29869361
While unconventional myosins interact with different stages of the endocytic pathway, they are ascribed a transport function that is secondary to the protein complexes that control organelle identity. Endosomes are...
10.
Malik R, Dysthe M, Ritt M, Sunahara R, Sivaramakrishnan S
Sci Rep
. 2017 Aug;
7(1):7749.
PMID: 28798477
FRET and BRET approaches are well established for detecting ligand induced GPCR-G protein interactions in cells. Currently, FRET/BRET assays rely on co-expression of GPCR and G protein, and hence depend...