Michael Ritt
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Explore the profile of Michael Ritt including associated specialties, affiliations and a list of published articles.
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Articles
20
Citations
285
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Recent Articles
11.
Gupte T, Malik R, Sommese R, Ritt M, Sivaramakrishnan S
Proc Natl Acad Sci U S A
. 2017 Mar;
114(14):3756-3761.
PMID: 28325873
Although individual G-protein-coupled receptors (GPCRs) are known to activate one or more G proteins, the GPCR-G-protein interaction is viewed as a bimolecular event involving the formation of a ternary ligand-GPCR-G-protein...
12.
Sommese R, Ritt M, Swanson C, Sivaramakrishnan S
J Biol Chem
. 2017 Jan;
292(7):2873-2880.
PMID: 28049730
Resolving the conformational dynamics of large multidomain proteins has proven to be a significant challenge. Here we use a variety of techniques to dissect the roles of individual protein kinase...
13.
Swanson C, Sommese R, Petersen K, Ritt M, Karslake J, Thomas D, et al.
PLoS One
. 2016 Oct;
11(10):e0162331.
PMID: 27706148
Protein kinase C α (PKCα) is a nodal regulator in several intracellular signaling networks. PKCα is composed of modular domains that interact with each other to dynamically regulate spatial-temporal function....
14.
Ritt M, Sivaramakrishnan S
Mol Pharmacol
. 2016 Jan;
89(4):407-12.
PMID: 26801393
Adenylyl cyclase (AC) activity relies on multiple effectors acting through distinct binding sites. Crystal structures have revealed the location of these sites, and biochemical studies have explored the kinetics of...
15.
Chen Q, Ritt M, Sivaramakrishnan S, Sun Y, Fan X
Lab Chip
. 2014 Oct;
14(24):4590-5.
PMID: 25312306
We achieve optofluidic lasers with a single molecular layer of gain, in which green fluorescent protein, dye-labeled bovine serum albumin, and dye-labeled DNA, are used as the gain medium and...
16.
Baker G, Chockley P, Yadav V, Doherty R, Ritt M, Sivaramakrishnan S, et al.
Cancer Res
. 2014 Jul;
74(18):5079-90.
PMID: 25038230
Natural killer (NK) cells safeguard against early tumor formation by destroying transformed target cells in a process referred to as NK immune surveillance. However, the immune escape mechanisms used by...
17.
Swanson C, Ritt M, Wang W, Lang M, Narayan A, Tesmer J, et al.
J Biol Chem
. 2014 May;
289(25):17812-29.
PMID: 24790081
Signaling proteins comprised of modular domains have evolved along with multicellularity as a method to facilitate increasing intracellular bandwidth. The effects of intramolecular interactions between modular domains within the context...
18.
Malik R, Ritt M, DeVree B, Neubig R, Sunahara R, Sivaramakrishnan S
J Biol Chem
. 2013 May;
288(24):17167-78.
PMID: 23629648
Although several recent studies have reported that GPCRs adopt multiple conformations, it remains unclear how subtle conformational changes are translated into divergent downstream responses. In this study, we report on...
19.
Chen Q, Zhang X, Sun Y, Ritt M, Sivaramakrishnan S, Fan X
Lab Chip
. 2013 Apr;
13(14):2679-81.
PMID: 23545541
We achieved optofluidic protein lasing using genetically encoded fluorescent protein FRET pairs linked by length-tunable peptides. Up to 25-fold reduction in the donor laser emission was observed when the donor...
20.
Ritt M, Guan J, Sivaramakrishnan S
J Biol Chem
. 2013 Feb;
288(13):8875-86.
PMID: 23393139
Focal Adhesion Kinase (FAK) is essential for cell migration and plays an important role in tumor metastasis. However, the complex intermolecular and intramolecular interactions that regulate FAK activity at the...