Michael R Waarts
Overview
Explore the profile of Michael R Waarts including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
115
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0
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Recent Articles
1.
Bowman R, Dunbar A, Mishra T, Xiao W, Waarts M, Maestre I, et al.
Cancer Cell
. 2024 Nov;
42(11):1955-1969.e7.
PMID: 39532065
Cancer evolution is a multifaceted process leading to dysregulation of cellular expansion and differentiation through somatic mutations and epigenetic dysfunction. Clonal expansion and evolution is driven by cell-intrinsic and -extrinsic...
2.
Waarts M, Mowla S, Boileau M, Martinez Benitez A, Sango J, Bagish M, et al.
Cancer Discov
. 2024 May;
14(10):1860-1878.
PMID: 38819218
Clonal hematopoiesis (CH) is a common premalignant state in the blood and confers an increased risk of blood cancers and all-cause mortality. Identification of therapeutic targets in CH has been...
3.
Dunbar A, Bowman R, Park Y, OConnor K, Izzo F, Myers R, et al.
Cancer Discov
. 2024 Jan;
14(5):737-751.
PMID: 38230747
Significance: Current JAK inhibitors to treat myeloproliferative neoplasms are ineffective at eradicating mutant cells. We developed an endogenously expressed Jak2V617F dual-recombinase knock-in/knock-out model to investigate Jak2V617F oncogenic reversion in vivo....
4.
Waarts M, Stonestrom A, Park Y, Levine R
J Clin Invest
. 2022 Apr;
132(8).
PMID: 35426374
Targeted therapies have come to play an increasingly important role in cancer therapy over the past two decades. This success has been made possible in large part by technological advances...
5.
Xiao W, Chan A, Waarts M, Mishra T, Liu Y, Cai S, et al.
Blood
. 2020 Sep;
137(10):1377-1391.
PMID: 32871587
Plasmacytoid dendritic cells (pDCs) are the principal natural type I interferon-producing dendritic cells. Neoplastic expansion of pDCs and pDC precursors leads to blastic plasmacytoid dendritic cell neoplasm (BPDCN), and clonal...
6.
Baeten J, Waarts M, Pruitt M, Chan W, Andrade J, de Jong J
Haematologica
. 2019 Jan;
104(7):1388-1395.
PMID: 30630989
Cancer stem cells have been strongly linked to resistance and relapse in many malignancies. However, purifying them from within the bulk tumor has been challenging, so their precise genetic and...
7.
Pruitt M, Marin W, Waarts M, de Jong J
J Vis Exp
. 2017 May;
(123).
PMID: 28518092
Heterogeneous cell populations, from either healthy or malignant tissues, may contain a population of cells characterized by a differential ability to efflux the DNA-binding dye Hoechst 33342. This "side population"...