Michael R Howitt
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Explore the profile of Michael R Howitt including associated specialties, affiliations and a list of published articles.
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20
Citations
4383
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Recent Articles
11.
Nico K, Tyner M, Howitt M
J Allergy Clin Immunol
. 2022 Aug;
150(3):580-582.
PMID: 35934085
No abstract available.
12.
Fung C, Howitt M
Immunity
. 2020 Mar;
52(3):426-428.
PMID: 32187512
Tuft cells are specialized taste-chemosensory cells that detect the presence of intestinal parasites and orchestrate type 2 immunity. In this issue of Immunity, McGinty et al. discover that parasitic worms,...
13.
Howitt M, Cao Y, Gologorsky M, Li J, Haber A, Biton M, et al.
Immunohorizons
. 2020 Jan;
4(1):23-32.
PMID: 31980480
Tuft cells are an epithelial cell type critical for initiating type 2 immune responses to parasites and protozoa in the small intestine. To respond to these stimuli, intestinal tuft cells...
14.
Wilen C, Lee S, Hsieh L, Orchard R, Desai C, Hykes Jr B, et al.
Science
. 2018 Apr;
360(6385):204-208.
PMID: 29650672
Complex interactions between host immunity and the microbiome regulate norovirus infection. However, the mechanism of host immune promotion of enteric virus infection remains obscure. The cellular tropism of noroviruses is...
15.
Haber A, Biton M, Rogel N, Herbst R, Shekhar K, Smillie C, et al.
Nature
. 2017 Nov;
551(7680):333-339.
PMID: 29144463
Intestinal epithelial cells absorb nutrients, respond to microbes, function as a barrier and help to coordinate immune responses. Here we report profiling of 53,193 individual epithelial cells from the small...
16.
Howitt M, Lavoie S, Michaud M, Blum A, Tran S, Weinstock J, et al.
Science
. 2016 Feb;
351(6279):1329-33.
PMID: 26847546
The intestinal epithelium forms an essential barrier between a host and its microbiota. Protozoa and helminths are members of the gut microbiota of mammals, including humans, yet the many ways...
17.
Lertsethtakarn P, Howitt M, Castellon J, Amieva M, Ottemann K
Mol Microbiol
. 2015 Jun;
97(6):1063-78.
PMID: 26061894
Chemotaxis is important for Helicobacter pylori to colonize the stomach. Like other bacteria, H. pylori uses chemoreceptors and conserved chemotaxis proteins to phosphorylate the flagellar rotational response regulator, CheY, and...
18.
Smith P, Howitt M, Panikov N, Michaud M, Gallini C, Bohlooly-Y M, et al.
Science
. 2013 Jul;
341(6145):569-73.
PMID: 23828891
Regulatory T cells (Tregs) that express the transcription factor Foxp3 are critical for regulating intestinal inflammation. Candidate microbe approaches have identified bacterial species and strain-specific molecules that can affect intestinal...
19.
Kostic A, Howitt M, Garrett W
Genes Dev
. 2013 Apr;
27(7):701-18.
PMID: 23592793
The animal and bacterial kingdoms have coevolved and coadapted in response to environmental selective pressures over hundreds of millions of years. The meta'omics revolution in both sequencing and its analytic...
20.