Michael R Howitt
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Explore the profile of Michael R Howitt including associated specialties, affiliations and a list of published articles.
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4383
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Recent Articles
1.
Gerrick E, Howitt M
Trends Microbiol
. 2025 Feb;
PMID: 39952813
The gut microbiota critically influences many aspects of host biology, from nutrient acquisition to immunological function, and is integral to metazoan life. While most microbiome research has focused on bacteria,...
2.
Buquicchio F, Fonseca R, Yan P, Wang F, Evrard M, Obers A, et al.
Immunity
. 2024 Jul;
57(9):2202-2215.e6.
PMID: 39043184
The memory CD8 T cell pool contains phenotypically and transcriptionally heterogeneous subsets with specialized functions and recirculation patterns. Here, we examined the epigenetic landscape of CD8 T cells isolated from...
3.
Billipp T, Fung C, Webeck L, Sargent D, Gologorsky M, Chen Z, et al.
Immunity
. 2024 May;
57(6):1243-1259.e8.
PMID: 38744291
Epithelial cells secrete chloride to regulate water release at mucosal barriers, supporting both homeostatic hydration and the "weep" response that is critical for type 2 immune defense against parasitic worms...
4.
Strine M, Fagerberg E, Darcy P, Barron G, Filler R, Alfajaro M, et al.
Sci Immunol
. 2024 Mar;
9(93):eadi7038.
PMID: 38517952
The persistent murine norovirus strain MNV is a model for human norovirus and enteric viral persistence. MNV causes chronic infection by directly infecting intestinal tuft cells, rare chemosensory epithelial cells....
5.
Gerrick E, Zlitni S, West P, Carter M, Mechler C, Olm M, et al.
Cell
. 2023 Dec;
187(1):62-78.e20.
PMID: 38096822
The microbiota influences intestinal health and physiology, yet the contributions of commensal protists to the gut environment have been largely overlooked. Here, we discover human- and rodent-associated parabasalid protists, revealing...
6.
Gerrick E, DeSchepper L, Mechler C, Joubert L, Dunker F, Colston T, et al.
mBio
. 2023 Nov;
14(6):e0227323.
PMID: 37962346
Environmental factors like climate change and captive breeding can impact the gut microbiota and host health. Therefore, conservation efforts for threatened species may benefit from understanding how these factors influence...
7.
Gerrick E, DeSchepper L, Mechler C, Joubert L, Dunker F, Colston T, et al.
bioRxiv
. 2023 Jun;
PMID: 37292851
Parabasalid protists recently emerged as keystone members of the mammalian microbiota with important effects on their host's health. However, the prevalence and diversity of parabasalids in wild reptiles and the...
8.
Fung C, Fraser L, Barron G, Gologorsky M, Atkinson S, Gerrick E, et al.
Proc Natl Acad Sci U S A
. 2023 May;
120(23):e2216908120.
PMID: 37253002
Succinate produced by the commensal protist () stimulates chemosensory tuft cells, resulting in intestinal type 2 immunity. Tuft cells express the succinate receptor SUCNR1, yet this receptor does not mediate...
9.
Gologorsky M, Mechler C, Forgo E, Charville G, Howitt M
Parasite Immunol
. 2023 Apr;
45(6):e12981.
PMID: 37038837
Schistosomiasis affects nearly 240 million people in predominately low- and middle-income countries and ranks second in the number of cases and socio-economic burden among all parasitic diseases. Despite the enormous...
10.
Billipp T, Fung C, Webeck L, Sargent D, Gologorsky M, McDaniel M, et al.
bioRxiv
. 2023 Mar;
PMID: 36993541
Tuft cells are solitary chemosensory epithelial cells that can sense lumenal stimuli at mucosal barriers and secrete effector molecules to regulate the physiology and immune state of their surrounding tissue....