Michael R Braden
Overview
Explore the profile of Michael R Braden including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
192
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Recent Articles
1.
James S, Ahmed S, Murphy S, Braden M, Belabassi Y, VanBrocklin H, et al.
ACS Chem Neurosci
. 2014 Apr;
5(7):519-24.
PMID: 24716794
Radiosynthesis of a fluorine-18 labeled organophosphate (OP) inhibitor of acetylcholinesterase (AChE) and subsequent positron emission tomography (PET) imaging using the tracer in the rat central nervous system are reported. The...
2.
Matti A, Mirzaei J, Rudolph J, Smith S, Newell J, Patel S, et al.
Bioorg Med Chem Lett
. 2013 Sep;
23(21):5931-5.
PMID: 24042010
Microwave accelerated reaction system (MARS) technology provided a good method to obtain selective and open isoxazole ligands that bind to and inhibit the Sxc- antiporter. The MARS provided numerous advantages,...
3.
Guo L, Suarez A, Braden M, Gerdes J, Thompson C
Bioorg Med Chem Lett
. 2009 Dec;
20(3):1194-7.
PMID: 20034789
Fluorophosphonate (FP) head groups were tethered to a variety of chromophores (C) via a triazole group and tested as FPC inhibitors of recombinant mouse (rMoAChE) and electric eel (EEAChE) acetylcholinesterase....
4.
Braden M, Nichols D
Mol Pharmacol
. 2007 Aug;
72(5):1200-9.
PMID: 17715398
We assessed the relative importance of two serine residues located near the top of transmembrane helix 5 of the human 5-HT(2A) receptor, comparing the wild type with S5.43(239)A or S5.46(242)A...
5.
Braden M, Parrish J, Naylor J, Nichols D
Mol Pharmacol
. 2006 Sep;
70(6):1956-64.
PMID: 17000863
Experiments were conducted to examine the molecular basis for the high affinity and potency of a new class of 5-HT(2A) receptor agonists, N-benzyl phenethylamines. Competition binding assays at several serotonin...
6.
McLean T, Parrish J, Braden M, Marona-Lewicka D, Gallardo-Godoy A, Nichols D
J Med Chem
. 2006 Sep;
49(19):5794-803.
PMID: 16970404
A series of conformationally restricted analogues of the hallucinogenic phenethylamine 1 (2,5-dimethoxy-4-bromophenethylamine, 2C-B) was synthesized to test several hypotheses concerning the bioactive conformation of phenethylamine ligands upon binding to the...
7.
McLean T, Chambers J, Parrish J, Braden M, Marona-Lewicka D, Kurrasch-Orbaugh D, et al.
J Med Chem
. 2006 Jul;
49(14):4269-74.
PMID: 16821786
A conformationally restricted analogue of mescaline, C-(4,5,6-trimethoxyindan-1-yl)-methanamine, was designed using a 5-HT(2A) receptor homology model. The compound possessed 3-fold higher affinity and potency than and efficacy equal to that of...
8.
Parrish J, Braden M, Gundy E, Nichols D
J Neurochem
. 2005 Nov;
95(6):1575-84.
PMID: 16277614
Experiments compared a series of phenethylamine hallucinogens with their phenylisopropylamine analogues for binding affinity and ability to stimulate serotonin 5-HT 2A receptor-mediated hydrolysis of phosphatidyl inositol in cells expressing cloned...