Microwave Accelerated Synthesis of Isoxazole Hydrazide Inhibitors of the System Xc- Transporter: Initial Homology Model

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2013 Sep 18

PMID 24042010

Citations 3

Authors

Afnan A Matti

Joseph Mirzaei

John Rudolph

Stephen A Smith

Jayme L Newell

Sarjubhai A Patel

Michael R Braden

Richard J Bridges

Nicholas R Natale

Affiliations

Soon will be listed here.

Abstract

Microwave accelerated reaction system (MARS) technology provided a good method to obtain selective and open isoxazole ligands that bind to and inhibit the Sxc- antiporter. The MARS provided numerous advantages, including: shorter time, better yield and higher purity of the product. Of the newly synthesized series of isoxazoles the salicyl hydrazide 6 exhibited the highest level of inhibitory activity in the transport assay. A homology model has been developed to summarize the SAR results to date, and provide a working hypothesis for future studies.

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