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Michael Pichichero

Explore the profile of Michael Pichichero including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 50
Citations 754
Followers 0
Related Specialties
Allergy & Immunology
Pediatrics
Infectious Diseases
Top 10 Co-Authors
Ravinder Kaur
Janet Casey
Naoko Fuji
Naveen Surendran
Minh Pham
Eduardo Gonzalez
Mark Blatter
Adriano Arguedas
Miwako Kobayashi
David P Greenberg
Published In
Vaccine
Pediatr Infect Dis J
J Infect Dis
Pediatrics
Otolaryngol Head Neck Surg
Affiliations
Soon will be listed here.
Recent Articles
1.
Comparison of Streptococcus pneumoniae nasopharyngeal colonization, serotype-specific and protein-specific antibody and cytokine levels in young children prior to, during and post COVID-19 pandemic
Fuji N, Gonzalez E, Salamone F, Bajorski P, Kaur R, Pichichero M
Vaccine . 2025 Mar; 54:126954. PMID: 40058284
Background: We studied changes in pneumococcal epidemiology and immunology in young children at pre-COVID, during-COVID and post-COVID time-frames. Methods: Pneumococci were cultured from nasopharynx and density semi-quantified at six healthy...
2.
Modeling conjugate vaccine and natural induced antibody correlates of protection for pneumococcal colonization and acute otitis media infection in young children
Pham M, Pichichero M
Vaccine . 2024 Sep; 42(26):126295. PMID: 39265455
We measured anti-pneumococcal serotype 19A vaccine-induced antibodies in 160 children (611 sera) after introduction of 13-valent pneumococcal conjugate vaccine and naturally-induced antibodies in 59 children (185 sera) after colonization and...
3.
Respiratory infection- and asthma-prone, low vaccine responder children demonstrate distinct mononuclear cell DNA methylation pathways
Martino D, Schultz N, Kaur R, van Haren S, Kresoje N, Hoch A, et al.
Clin Epigenetics . 2024 Jul; 16(1):85. PMID: 38961479
Background: Infants with frequent viral and bacterial respiratory infections exhibit compromised immunity to routine immunizations. They are also more likely to develop chronic respiratory diseases in later childhood. This study...
4.
Anticipated Effects of Higher-valency Pneumococcal Conjugate Vaccines on Colonization and Acute Otitis Media
Kaur R, Schulz S, Sherman A, Andrejko K, Kobayashi M, Pichichero M
Pediatr Infect Dis J . 2024 Jun; 43(10):1004-1010. PMID: 38838209
Background: Bacterial etiologies of acute otitis media (AOM) have shifted from the introduction of pneumococcal conjugate vaccines (PCVs), antibiotic selection and competition among species. We characterized Streptococcus pneumoniae ( Spn...
5.
Respiratory Infection- and Asthma-prone, Low Vaccine Responder Children Demonstrate Distinct Mononuclear Cell DNA Methylation Pathways
Martino D, Schultz N, Kaur R, Haren S, Kresoje N, Hoch A, et al.
Res Sq . 2024 Apr; PMID: 38645021
Background: Infants with frequent viral and bacterial respiratory infections exhibit compromised immunity to routine immunisations. They are also more likely to develop chronic respiratory diseases in later childhood. This study...
6.
Pneumococci Isolated From Children in Community-Based Practice Differ From Isolates Identified by Population- and Laboratory-Based Invasive Disease Surveillance
Kaur R, Gierke R, McGee L, Gonzalez E, Kobayashi M, Pichichero M
J Infect Dis . 2024 Apr; 230(5):1243-1252. PMID: 38591247
Background: Characterizing strains causing noninvasive and invasive pneumococcal disease (IPD) may inform the impact of new pneumococcal conjugate vaccines (PCVs). Methods: During 2011-2019, among children aged 6-36 months, pneumococcal serotype...
7.
Naturally-induced serum antibody levels in children to pneumococcal polysaccharide 15B that correlate with protection from nasopharyngeal colonization but anti-serotype 15B antibody has low functional cross-reactivity with serotype 15C
Kaur R, Gonzalez E, Pham M, Pichichero M
Vaccine . 2023 Nov; 41(48):7265-7273. PMID: 37925318
Background: Serotypes 15B and 15C have been added to new different pneumococcal-conjugate vaccines (PCV20 and V116, respectively). We determined a serum anti-15B antibody level that would be a correlate of...
8.
Expression conditions and characterization of a novelly constructed lipoprotein intended as a vaccine to prevent human Haemophilus influenzae infections
Kaur R, Mangiafesto J, Pryharski K, Rasam S, Zagursky R, Pichichero M
J Biol Chem . 2023 Jul; 299(8):105031. PMID: 37437888
Bacterial lipoproteins are structurally divided into two groups, based on their lipid moieties: diacylated (present in Gram-positive bacteria) and triacylated (present in some Gram-positive and most Gram-negative bacteria). Diacylated and...
9.
Colonization, Density, and Antibiotic Resistance of Streptococcus pneumoniae, Haemophilus Influenzae, and Moraxella catarrhalis among PCV13-Vaccinated Infants in the First Six Months of Life in Rochester, New York: A Cohort Study
Kaur R, Pichichero M
J Pediatric Infect Dis Soc . 2023 Jan; 12(3):135-142. PMID: 36645216
Background: Streptococcus pneumoniae (Spn), Haemophilus influenzae (Hflu), and Moraxella catarrhalis (Mcat) nasopharyngeal colonization precedes disease pathogenesis and varies among settings and countries. We sought to assess colonization prevalence, density, Spn...
10.
Acute otitis media pneumococcal disease burden and nasopharyngeal colonization in children due to serotypes included and not included in current and new pneumococcal conjugate vaccines
Pichichero M, Malley R, Kaur R, Zagursky R, Anderson P
Expert Rev Vaccines . 2022 Dec; 22(1):118-138. PMID: 36565291
Introduction: Despite the introduction of effective pneumococcal conjugate vaccines (PCV), Streptococcus pneumoniae remains a major cause of acute otitis media (AOM) worldwide. New, higher valency vaccines that offer broader serotype...