Michael Pargett
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Explore the profile of Michael Pargett including associated specialties, affiliations and a list of published articles.
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27
Citations
443
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Recent Articles
1.
DeCuzzi N, Kosaisawe N, Pargett M, Cabel M, Albeck J
Methods Mol Biol
. 2025 Feb;
2882:47-79.
PMID: 39992504
5'-Adenosine monophosphate-activated protein kinase (AMPK) senses cellular metabolic status and reflects the balance between ATP production and ATP usage. This balance varies from cell to cell and changes over time,...
2.
DeCuzzi N, Hu J, Xu F, Rodriguez B, Pargett M, Albeck J
bioRxiv
. 2024 Dec;
PMID: 39677763
Cell fate decisions are regulated by intricate signaling networks, with Extracellular signal-Regulated Kinase (ERK) being a central regulator. However, ERK is rarely the only signaling pathway involved, creating a need...
3.
DeCuzzi N, Oberbauer D, Chmiel K, Pargett M, Ferguson J, Murphy D, et al.
Am J Respir Cell Mol Biol
. 2024 Nov;
PMID: 39556370
Spatially coordinated ERK signaling events ("SPREADs") transmit radially from a central point to adjacent cells via secreted ligands for EGFR and other receptors. SPREADs maintain homeostasis in non-pulmonary epithelia, but...
4.
Ram A, Pargett M, Choi Y, Murphy D, Cabel M, Kosaisawe N, et al.
bioRxiv
. 2024 Feb;
PMID: 38405841
The Ras/ERK pathway drives cell proliferation and other oncogenic behaviors, and quantifying its activity is of high interest in cancer diagnosis and therapy. Pathway activation is often assayed by measuring...
5.
DeCuzzi N, Oberbauer D, Chmiel K, Pargett M, Ferguson J, Murphy D, et al.
bioRxiv
. 2024 Feb;
PMID: 38352523
Rationale: Spatially coordinated ERK signaling events ("SPREADs") transmit radially from a central point to adjacent cells via secreted ligands for EGFR and other receptors. SPREADs maintain homeostasis in non-pulmonary epithelia,...
6.
Ram A, Murphy D, DeCuzzi N, Patankar M, Hu J, Pargett M, et al.
Biochem J
. 2023 Dec;
480(23):1909-1928.
PMID: 38038975
Signaling by the extracellular signal-regulated kinase (ERK) pathway controls many cellular processes, including cell division, death, and differentiation. In this second installment of a two-part review, we address the question...
7.
Ram A, Murphy D, DeCuzzi N, Patankar M, Hu J, Pargett M, et al.
Biochem J
. 2023 Dec;
480(23):1887-1907.
PMID: 38038974
Extracellular signal-regulated kinase (ERK) has long been studied as a key driver of both essential cellular processes and disease. A persistent question has been how this single pathway is able...
8.
Sparta B, Kosaisawe N, Pargett M, Patankar M, DeCuzzi N, Albeck J
Elife
. 2023 Sep;
12.
PMID: 37698461
mTORC1 senses nutrients and growth factors and phosphorylates downstream targets, including the transcription factor TFEB, to coordinate metabolic supply and demand. These functions position mTORC1 as a central controller of...
9.
Pargett M, Ram A, Murthy V, Davies A
Methods Mol Biol
. 2023 Apr;
2634:285-314.
PMID: 37074584
Paracrine signaling is a fundamental process regulating tissue development, repair, and pathogenesis of diseases such as cancer. Herein we describe a method for quantitatively measuring paracrine signaling dynamics, and resultant...
10.
Guo L, Zhu K, Pargett M, Contreras A, Tsai P, Qing Q, et al.
iScience
. 2021 Nov;
24(11):103240.
PMID: 34746704
Intracellular signaling dynamics play fundamental roles in cell biology. Precise modulation of the amplitude, duration, and frequency of signaling activation will be a powerful approach to investigate molecular mechanisms as...