Michael P Philpott
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Explore the profile of Michael P Philpott including associated specialties, affiliations and a list of published articles.
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45
Citations
1326
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Recent Articles
21.
Akinduro O, Sully K, Patel A, Robinson D, Chikh A, McPhail G, et al.
J Invest Dermatol
. 2016 Mar;
136(7):1460-1470.
PMID: 27021405
Epidermal keratinocytes migrate through the epidermis up to the granular layer where, on terminal differentiation, they progressively lose organelles and convert into anucleate cells or corneocytes. Our report explores the...
22.
Langan E, Philpott M, Kloepper J, Paus R
Exp Dermatol
. 2015 Aug;
24(12):903-11.
PMID: 26284830
For almost a quarter of a century, ex vivo studies of human scalp hair follicles (HFs) have permitted major advances in hair research, spanning diverse fields such as chronobiology, endocrinology,...
23.
Upton J, Hannen R, Bahta A, Farjo N, Farjo B, Philpott M
J Invest Dermatol
. 2015 Feb;
135(5):1244-1252.
PMID: 25647436
Dermal papilla cells (DPCs) taken from male androgenetic alopecia (AGA) patients undergo premature senescence in vitro in association with the expression of p16(INK4a), suggesting that DPCs from balding scalp are...
24.
Al-Nuaimi Y, Hardman J, Biro T, Haslam I, Philpott M, Toth B, et al.
J Invest Dermatol
. 2013 Sep;
134(3):610-619.
PMID: 24005054
The hair follicle (HF) is a continuously remodeled mini organ that cycles between growth (anagen), regression (catagen), and relative quiescence (telogen). As the anagen-to-catagen transformation of microdissected human scalp HFs...
25.
Chikh A, Matin R, Senatore V, Hufbauer M, Lavery D, Raimondi C, et al.
EMBO J
. 2011 Sep;
30(20):4261-73.
PMID: 21897369
iASPP, an inhibitory member of the ASPP (apoptosis stimulating protein of p53) family, is an evolutionarily conserved inhibitor of p53 which is frequently upregulated in human cancers. However, little is...
26.
Ramot Y, Tiede S, Biro T, Abu Bakar M, Sugawara K, Philpott M, et al.
PLoS One
. 2011 Aug;
6(7):e22564.
PMID: 21818338
Background: Rapidly regenerating tissues need sufficient polyamine synthesis. Since the hair follicle (HF) is a highly proliferative mini-organ, polyamines may also be important for normal hair growth. However, the role...
27.
Nadendla S, Hazan A, Ward M, Harper L, Moutasim K, Bianchi L, et al.
PLoS One
. 2011 Jun;
6(5):e20271.
PMID: 21633508
The GLI (GLI1/GLI2) transcription factors have been implicated in the development and progression of prostate cancer although our understanding of how they actually contribute to the biology of these common...
28.
Ruge F, Glavini A, Gallimore A, Richards H, Thomas C, ODonnell V, et al.
J Invest Dermatol
. 2010 Dec;
131(3):572-9.
PMID: 21160494
Defolliculated (Gsdma3(Dfl)/+) mice have a hair loss phenotype that involves an aberrant hair cycle, altered sebaceous gland differentiation with reduced sebum production, chronic inflammation, and ultimately the loss of the...
29.
Hannen R, Michael A, Jaulim A, Bhogal R, Burrin J, Philpott M
Biochem Biophys Res Commun
. 2010 Nov;
404(1):62-7.
PMID: 21094146
Cortisol-based therapy is one of the most potent anti-inflammatory treatments available for skin conditions including psoriasis and atopic dermatitis. Previous studies have investigated the steroidogenic capabilities of keratinocytes, though none...
30.
Teh M, Gemenetzidis E, Chaplin T, Young B, Philpott M
Mol Cancer
. 2010 Mar;
9:45.
PMID: 20187950
Background: The human cell cycle transcription factor FOXM1 is known to play a key role in regulating timely mitotic progression and accurate chromosomal segregation during cell division. Deregulation of FOXM1...