Michael P Kladde
Overview
Explore the profile of Michael P Kladde including associated specialties, affiliations and a list of published articles.
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Articles
41
Citations
969
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Recent Articles
1.
Barrios E, Balzano-Nogueira L, Polcz V, Rodhouse C, Leary J, Darden D, et al.
Front Immunol
. 2024 Dec;
15:1478471.
PMID: 39691721
Introduction: Despite continued improvement in post-sepsis survival, long term morbidity and mortality remain high. Chronic critical illness (CCI), defined as persistent inflammation and organ injury requiring prolonged intensive care, is...
2.
Barrios E, Leary J, Darden D, Rincon J, Willis M, Polcz V, et al.
Front Immunol
. 2024 May;
15:1355405.
PMID: 38720891
Introduction: Sepsis engenders distinct host immunologic changes that include the expansion of myeloid-derived suppressor cells (MDSCs). These cells play a physiologic role in tempering acute inflammatory responses but can persist...
3.
Barrios E, Rincon J, Willis M, Polcz V, Leary J, Darden D, et al.
Shock
. 2024 May;
62(2):208-216.
PMID: 38713581
Postsepsis early mortality is being replaced by survivors who experience either a rapid recovery and favorable hospital discharge or the development of chronic critical illness with suboptimal outcomes. The underlying...
4.
Zhou M, Riva A, Gauthier M, Kladde M, Ferl R, Paul A
Biol Direct
. 2024 Apr;
19(1):33.
PMID: 38689301
Background: The Advanced Plant Experiment-04 - Epigenetic Expression (APEX-04-EpEx) experiment onboard the International Space Station examined the spaceflight-altered cytosine methylation in two genetic lines of Arabidopsis thaliana, wild-type Col-0 and...
5.
Murray K, Brant J, Spradlin R, Thome T, Laitano O, Ryan T, et al.
Am J Physiol Regul Integr Comp Physiol
. 2023 Dec;
326(2):R160-R175.
PMID: 38047316
The effect of exertional heat stroke (EHS) exposure on skeletal muscles is incompletely understood. Muscle weakness is an early symptom of EHS but is not considered a major target of...
6.
Murray K, Brant J, Kladde M, Clanton T
Physiol Genomics
. 2022 Oct;
54(12):486-500.
PMID: 36215393
Evidence from human epidemiological studies suggests that exertional heat stroke (EHS) results in an elevated risk of long-term cardiovascular and systemic disease. Previous results using a preclinical mouse model of...
7.
Knight P, Gauthier M, Pardo C, Darst R, Kapadia K, Browder H, et al.
Bioinformatics
. 2021 Jun;
37(24):4857-4859.
PMID: 34125875
Summary: Differential DNA methylation and chromatin accessibility are associated with disease development, particularly cancer. Methods that allow profiling of these epigenetic mechanisms in the same reaction and at the single-molecule...
8.
Murray K, Brant J, Iwaniec J, Sheikh L, de Carvalho L, Garcia C, et al.
J Physiol
. 2020 Oct;
599(1):119-141.
PMID: 33037634
Key Points: Exposure to exertional heat stroke (EHS) has been linked to increased long-term decrements of health. Epigenetic reprogramming is involved in the response to heat acclimation; however, whether the...
9.
Lorentsen K, Cho J, Luo X, Zuniga A, Urban Jr J, Zhou L, et al.
Nat Commun
. 2018 Jul;
9(1):2901.
PMID: 30026604
In the originally published version of this Article, the affiliation details for Dorina Avram incorrectly included "Department of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida, 2015...
10.
Lorentsen K, Cho J, Luo X, Zuniga A, Urban Jr J, Zhou L, et al.
Nat Commun
. 2018 Apr;
9(1):1679.
PMID: 29700302
During helminth infection and allergic asthma, naive CD4 T-cells differentiate into cytokine-producing Type-2 helper (Th2) cells that resolve the infection or induce asthma-associated pathology. Mechanisms regulating the Th2 differentiation in...