Michael P Feneley
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Explore the profile of Michael P Feneley including associated specialties, affiliations and a list of published articles.
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58
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1052
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Recent Articles
1.
Strange G, Feneley M, Prior D, Muller D, Venkataraman P, Situ Y, et al.
Am Heart J Plus
. 2024 Dec;
48:100485.
PMID: 39687290
Many severe aortic stenosis (AS) cases are undetected and/or not considered for potentially life-saving treatment, with a persistent male-bias reported among those undergoing aortic valve replacement (AVR). We evaluated the...
2.
Yu Z, Gong H, Kesteven S, Guo Y, Wu J, Li J, et al.
Nat Cardiovasc Res
. 2024 Aug;
1(6):577-591.
PMID: 39195867
Pressure overload-induced cardiac hypertrophy is a maladaptive response with poor outcomes and limited treatment options. The transient receptor potential melastatin 4 (TRPM4) ion channel is key to activation of a...
3.
Guo Y, Cheng D, Yu Z, Schiatti T, Chan A, Hill A, et al.
J Physiol
. 2023 Dec;
602(18):4363-4386.
PMID: 38098265
The transient receptor potential melastatin 4 (TRPM4) channel contributes extensively to cardiac electrical activity, especially cardiomyocyte action potential formation. Mechanical stretch can induce changes in heart rate and rhythm, and...
4.
Namasivayam M, Meredith T, Muller D, Roy D, Roy A, Kovacic J, et al.
Front Cardiovasc Med
. 2023 Jun;
10:1153814.
PMID: 37324638
Background: Moderate severity aortic stenosis (AS) is poorly understood, is associated with subclinical myocardial dysfunction, and can lead to adverse outcome rates that are comparable to severe AS. Factors associated...
5.
Wu J, Nicks A, Skowno J, Feneley M, Graham R, Iismaa S
J Vis Exp
. 2022 Jun;
(184).
PMID: 35723494
Murine surgical models play an important role in preclinical research. Mechanistic insights into myocardial regeneration after cardiac injury may be gained from cardiothoracic surgery models in 0-14-day-old mice, the cardiomyocytes...
6.
Involvement of GPR37L1 in murine blood pressure regulation and human cardiac disease pathophysiology
Mouat M, Coleman J, Wu J, Dos Remedios C, Feneley M, Graham R, et al.
Am J Physiol Heart Circ Physiol
. 2021 Sep;
321(4):H807-H817.
PMID: 34533400
Multiple mouse lines lacking the orphan G protein-coupled receptor, GPR37L1, have elicited disparate cardiovascular phenotypes. The first knockout mice study to be published reported a marked elevation in systolic blood...
7.
Modified N-linked glycosylation status predicts trafficking defective human Piezo1 channel mutations
Li J, Ng C, Cheng D, Zhou Z, Yao M, Guo Y, et al.
Commun Biol
. 2021 Sep;
4(1):1038.
PMID: 34489534
Mechanosensitive channels are integral membrane proteins that sense mechanical stimuli. Like most plasma membrane ion channel proteins they must pass through biosynthetic quality control in the endoplasmic reticulum that results...
8.
Guo Y, Yu Z, Wu J, Gong H, Kesteven S, Iismaa S, et al.
Elife
. 2021 Jun;
10.
PMID: 34190686
Pathological left ventricular hypertrophy (LVH) occurs in response to pressure overload and remains the single most important clinical predictor of cardiac mortality. The molecular pathways in the induction of pressure...
9.
Yu Z, Gong H, Wu J, Dai Y, Kesteven S, Fatkin D, et al.
Front Cell Dev Biol
. 2021 Mar;
9:639509.
PMID: 33659256
Rationale: Gq-coupled receptors are thought to play a critical role in the induction of left ventricular hypertrophy (LVH) secondary to pressure overload, although mechano-sensitive channel activation by a variety of...
10.
Nicks A, Kesteven S, Li M, Wu J, Chan A, Naqvi N, et al.
Sci Rep
. 2020 Sep;
10(1):15318.
PMID: 32948799
Animal models of pressure overload are valuable for understanding hypertensive heart disease. We characterised a surgical model of pressure overload-induced hypertrophy in C57BL/6J mice produced by suprarenal aortic constriction (SAC)....