Michael Overduin
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Explore the profile of Michael Overduin including associated specialties, affiliations and a list of published articles.
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110
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2667
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Recent Articles
1.
Chan J, Tabatabaei Dakhili S, Lorenzana-Carrillo M, Gopal K, Pulente S, Greenwell A, et al.
Cell Rep
. 2024 Aug;
43(8):114573.
PMID: 39093701
Growth differentiation factor 15 (GDF15) is a peptide with utility in obesity, as it decreases appetite and promotes weight loss. Because obesity increases the risk for type 2 diabetes (T2D)...
2.
Hussein S, Bhat R, Overduin M, LaPointe P
EMBO Rep
. 2024 Jun;
25(8):3532-3546.
PMID: 38937628
Hsp90 is a molecular chaperone that acts on its clients through an ATP-dependent and conformationally dynamic functional cycle. The cochaperone Accelerator of Hsp90 ATPase, or Ahsa1, is the most potent...
3.
Kervin T, Overduin M
BMC Biol
. 2024 Feb;
22(1):46.
PMID: 38414038
Membranes are protein and lipid structures that surround cells and other biological compartments. We present a conceptual model wherein all membranes are organized into structural and functional zones. The assembly...
4.
Overduin M, Bhat R
Biochim Biophys Acta Biomembr
. 2024 Feb;
1866(4):184305.
PMID: 38408696
The proteolipid code determines how cytosolic proteins find and remodel membrane surfaces. Here, we investigate how this process works with sorting nexins Snx1 and Snx3. Both proteins form sorting machines...
5.
Iyamu U, Vinals D, Tornyigah B, Arango E, Bhat R, Adra T, et al.
Front Cell Infect Microbiol
. 2023 Jul;
13:1202276.
PMID: 37396303
During infection in pregnancy, VAR2CSA is expressed on the surface of infected erythrocytes (IEs) and mediates their sequestration in the placenta. As a result, antibodies to VAR2CSA are largely restricted...
6.
Overduin M, Bhat R, Kervin T
Viruses
. 2023 Feb;
15(2).
PMID: 36851661
Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are emerging rapidly and offer surfaces that are optimized for recognition of host cell membranes while also evading antibodies arising from...
7.
Overduin M, Kervin T, Klarenbach Z, Adra T, Bhat R
Biophys Chem
. 2023 Feb;
295:106971.
PMID: 36801589
Structures can now be predicted for any protein using programs like AlphaFold and Rosetta, which rely on a foundation of experimentally determined structures of architecturally diverse proteins. The accuracy of...
8.
Jama M, Ahmed M, Jutla A, Wiethan C, Kumar J, Moon T, et al.
Comput Biol Med
. 2022 Dec;
152:106442.
PMID: 36566625
SHP2 (Src homology-2 domain-containing protein tyrosine phosphatase-2) is a cytoplasmic protein -tyrosine phosphatase encoded by the gene PTPN11. It plays a crucial role in regulating cell growth and differentiation. Specifically,...
9.
Overduin M, Tran A, Eekels D, Overduin F, Kervin T
Membranes (Basel)
. 2022 Nov;
12(11).
PMID: 36422153
Membrane proteins are broadly classified as transmembrane (TM) or peripheral, with functions that pertain to only a single bilayer at a given time. Here, we explicate a class of proteins...
10.
Han L, Nguyen L, Schmidt E, Esmaili M, Kitova E, Overduin M, et al.
Anal Chem
. 2022 Nov;
94(46):16042-16049.
PMID: 36367338
Interactions between glycan-binding proteins (GBPs) and glycosphingolipids (GSLs) are involved in numerous physiological and pathophysiological processes. Many model membrane systems are available for studying GBP-GSL interactions, but a systematic investigation...