Michael Ohh
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Explore the profile of Michael Ohh including associated specialties, affiliations and a list of published articles.
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78
Citations
3018
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Recent Articles
1.
Hubert M, Stuart S, Ohh M
Discov Oncol
. 2024 Oct;
15(1):595.
PMID: 39466364
Hypoxia-inducible factors (HIFs) are key transcriptional mediators of the hypoxic response and are implicated in oncogenesis. HIFα is regulated by a well-characterized, oxygen-dependent degradation pathway involving the von Hippel Lindau...
2.
He W, Gasmi-Seabrook G, Ikura M, Lee J, Ohh M
Proc Natl Acad Sci U S A
. 2024 Sep;
121(37):e2408104121.
PMID: 39231207
Prolyl-hydroxylation is an oxygen-dependent posttranslational modification (PTM) that is known to regulate fibril formation of collagenous proteins and modulate cellular expression of hypoxia-inducible factor (HIF) α subunits. However, our understanding...
3.
Stuart S, Tarade D, Ohh M
Sci Rep
. 2024 Jun;
14(1):14799.
PMID: 38926538
The oxygen-labile transcription factor called hypoxia-inducible factor (HIF) is responsible for the cellular and organismal adaptive response to reduced oxygen availability. Deregulation of HIF is associated with the pathogenesis of...
4.
Ferens F, Taber C, Stuart S, Hubert M, Tarade D, Lee J, et al.
Commun Biol
. 2024 Feb;
7(1):240.
PMID: 38418569
Pacak-Zhuang syndrome is caused by mutations in the EPAS1 gene, which encodes for one of the three hypoxia-inducible factor alpha (HIFα) paralogs HIF2α and is associated with defined but varied...
5.
Valencia-Sama I, Kee L, Christopher G, Ohh M, Layeghifard M, Shlien A, et al.
Cancer Res Commun
. 2023 Nov;
3(12):2608-2622.
PMID: 38032104
Significance: These findings highlight the translatability between zebrafish and murine models, provide evidence of aberrant RAS-MAPK signaling as an adaptive mechanism of resistance to lorlatinib, and demonstrate the clinical potential...
6.
Ting K, Yu P, Dow R, Floro E, Ibrahim H, Scipione C, et al.
J Immunol
. 2023 Sep;
211(10):1561-1577.
PMID: 37756544
Lipid accumulation in macrophages (Mφs) is a hallmark of atherosclerosis, yet how lipid accumulation affects inflammatory responses through rewiring of Mφ metabolism is poorly understood. We modeled lipid accumulation in...
7.
Ohh M, Taber C, Ferens F, Tarade D
Elife
. 2022 Aug;
11.
PMID: 36040300
von Hippel-Lindau (VHL) disease is a rare hereditary cancer syndrome that causes a predisposition to renal clear-cell carcinoma, hemangioblastoma, pheochromocytoma, and autosomal-recessive familial polycythemia. pVHL is the substrate conferring subunit...
8.
Grozavu I, Stuart S, Lyakisheva A, Yao Z, Pathmanathan S, Ohh M, et al.
J Mol Biol
. 2021 Dec;
434(2):167392.
PMID: 34896362
KRAS is one of the most frequently mutated oncogenes in human cancers. Despite nearly 40 years of research, KRAS remains largely undruggable, in part due to an incomplete understanding of...
9.
Huang R, Meens J, Yuzwa S, Ailles L, Ohh M, Robinson C
Biochem Biophys Res Commun
. 2021 Nov;
585:196-202.
PMID: 34813980
Cancer stem cells have an important role in tumour biology. While their identity in haematological malignancies is clearly defined, stem cell identity remains elusive in some solid tumours. Clear cell...
10.
Gebregiworgis T, Kano Y, St-Germain J, Radulovich N, Udaskin M, Mentes A, et al.
Nat Commun
. 2021 Nov;
12(1):6274.
PMID: 34725361
Cancer cells bearing distinct KRAS mutations exhibit variable sensitivity to SHP2 inhibitors (SHP2i). Here we show that cells harboring KRAS Q61H are uniquely resistant to SHP2i, and investigate the underlying...