Michael Nikolaou
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Explore the profile of Michael Nikolaou including associated specialties, affiliations and a list of published articles.
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29
Citations
266
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Recent Articles
1.
Eales B, Smith J, Pouya N, Hudson C, Tam V, Nikolaou M
Comput Chem Eng
. 2025 Jan;
192.
PMID: 39781207
Treatment of serious bacterial infections with antimicrobial agents, such as antibiotics, is a major clinical challenge, because of growing bacterial resistance to multiple agents. Combination therapy (i.e. combined dosing of...
2.
Hudson C, Smith J, Eales B, Nikolaou M, Tam V
Int J Antimicrob Agents
. 2023 Jul;
62(4):106924.
PMID: 37433386
Objective: The prevalence of drug resistance in pathogens such as HIV and selected bacteria has been steadily rising, resulting in an increased need for using multiple agents concurrently. Agents used...
3.
Nikolaou M, Tam V
Pharmaceutics
. 2023 Jun;
15(6).
PMID: 37376120
Rapid in vitro assessment of antimicrobial drug efficacy under clinically relevant pharmacokinetic conditions is an essential element of both drug development and clinical use. Here, we present a comprehensive overview...
4.
Bhagunde P, Nikolaou M, Tam V
AIChE J
. 2023 May;
61(8):2385-2393.
PMID: 37206682
In typical in vitro tests for clinical use or development of antibiotics, samples from a bacterial population are exposed to an antibiotic at various concentrations. The resulting data can then...
5.
Singh G, Orman M, Conrad J, Nikolaou M
PLoS Comput Biol
. 2023 Jan;
19(1):e1010243.
PMID: 36649322
A small fraction of infectious bacteria use persistence as a strategy to survive exposure to antibiotics. Periodic pulse dosing of antibiotics has long been considered a potentially effective strategy towards...
6.
Kesisoglou I, Eales B, Merlau P, Tam V, Nikolaou M
Comput Methods Programs Biomed
. 2022 Nov;
227:107212.
PMID: 36335752
Background: Model-based analysis of longitudinal optical density measurements from a bacterial suspension exposed to antibiotics has been proposed as a potentially efficient and effective method for extracting useful information to...
7.
Nikolaou M
Sci Rep
. 2022 Apr;
12(1):7077.
PMID: 35490159
The COVID-19 epidemic brought to the forefront the value of mathematical modelling for infectious diseases as a guide to help manage a formidable challenge for human health. A standard dynamic...
8.
Kesisoglou I, Tam V, Tomaras A, Nikolaou M
Comput Chem Eng
. 2022 Mar;
158.
PMID: 35250117
Time-kill experiments can discern the pharmacodynamics of infectious bacteria exposed to antibiotics in vitro, and thus help guide the design of effective therapies for challenging clinical infections. This task is...
9.
Nikolaou M
Comput Chem Eng
. 2021 Dec;
157:107615.
PMID: 34961800
The COVID-19 crisis popularized the importance of mathematical modeling for managing epidemics. A celebrated pertinent model was developed by Kermack and McKendrick about a century ago. A simplified version of...
10.
Kesisoglou I, Eales B, Ledesma K, Merlau P, Tam V, Wang W, et al.
Comput Chem Eng
. 2021 Dec;
155.
PMID: 34924641
Combination therapy for treatment of multi-drug resistant bacterial infections is becoming common. In vitro testing of drug combinations under realistic pharmacokinetic conditions is needed before a corresponding combination is eventually...