Michael Minaai
Overview
Explore the profile of Michael Minaai including associated specialties, affiliations and a list of published articles.
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11
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521
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Recent Articles
1.
Novelli F, Yoshikawa Y, Vitto V, Modesti L, Minaai M, Pastorino S, et al.
Proc Natl Acad Sci U S A
. 2024 Jul;
121(29):e2405231121.
PMID: 38990952
We report that ~1.8% of all mesothelioma patients and 4.9% of those younger than 55, carry rare germline variants of the BRCA1 associated RING domain 1 ( gene that were...
2.
Carbone M, Minaai M, Takinishi Y, Pagano I, Yang H
J Transl Med
. 2023 Oct;
21(1):749.
PMID: 37880686
Mesothelioma is a cancer typically caused by asbestos. Mechanistically, asbestos carcinogenesis has been linked to the asbestos-induced release of HMGB1 from the nucleus to the cytoplasm, where HMGB1 promotes autophagy...
3.
Suarez J, Novelli F, Goto K, Ehara M, Steele M, Kim J, et al.
Proc Natl Acad Sci U S A
. 2023 Sep;
120(39):e2307999120.
PMID: 37729199
Asbestos is the main cause of malignant mesothelioma. Previous studies have linked asbestos-induced mesothelioma to the release of HMGB1 from the nucleus to the cytoplasm, and from the cytoplasm to...
4.
Bononi A, Wang Q, Zolondick A, Bai F, Steele-Tanji M, Suarez J, et al.
Proc Natl Acad Sci U S A
. 2023 Jan;
120(4):e2217840120.
PMID: 36656861
is a powerful tumor suppressor gene characterized by haplo insufficiency. Individuals carrying germline mutations often develop mesothelioma, an aggressive malignancy of the serosal layers covering the lungs, pericardium, and abdominal...
5.
Carbone M, Pass H, Ak G, Alexander Jr H, Baas P, Baumann F, et al.
J Thorac Oncol
. 2022 Apr;
17(7):873-889.
PMID: 35462085
The most common malignancies that develop in carriers of BAP1 germline mutations include diffuse malignant mesothelioma, uveal and cutaneous melanoma, renal cell carcinoma, and less frequently, breast cancer, several types...
6.
BAP1 forms a trimer with HMGB1 and HDAC1 that modulates gene × environment interaction with asbestos
Novelli F, Bononi A, Wang Q, Bai F, Patergnani S, Kricek F, et al.
Proc Natl Acad Sci U S A
. 2021 Nov;
118(48).
PMID: 34815344
Carriers of heterozygous germline mutations () are affected by the "BAP1 cancer syndrome." Although they can develop almost any cancer type, they are unusually susceptible to asbestos carcinogenesis and mesothelioma....
7.
Bononi A, Goto K, Ak G, Yoshikawa Y, Emi M, Pastorino S, et al.
Proc Natl Acad Sci U S A
. 2020 Dec;
117(52):33466-33473.
PMID: 33318203
Rare biallelic gene mutations cause Bloom syndrome. Whether heterozygous germline mutations () cause human cancer remains unclear. We sequenced the germline DNA of 155 mesothelioma patients (33 familial and 122...
8.
Xue J, Suarez J, Minaai M, Li S, Gaudino G, Pass H, et al.
J Cell Physiol
. 2020 Oct;
236(5):3406-3419.
PMID: 33107103
High-mobility group box 1 (HMGB1) was initially recognized as a ubiquitous nuclear protein involved in maintaining the nucleosome integrity and facilitating gene transcription. HMGB1 has since been reevaluated to be...
9.
Carbone M, Adusumilli P, Alexander Jr H, Baas P, Bardelli F, Bononi A, et al.
CA Cancer J Clin
. 2019 Jul;
69(5):402-429.
PMID: 31283845
Mesothelioma affects mostly older individuals who have been occupationally exposed to asbestos. The global mesothelioma incidence and mortality rates are unknown, because data are not available from developing countries that...
10.
Pastorino S, Yoshikawa Y, Pass H, Emi M, Nasu M, Pagano I, et al.
J Clin Oncol
. 2018 Oct;
:JCO2018790352.
PMID: 30376426
Purpose: We hypothesized that four criteria could help identify malignant mesotheliomas (MMs) most likely linked to germline mutations of BAP1 or of other genes: family history of MM, BAP1-associated cancers,...