Sandra Pastorino
Overview
Explore the profile of Sandra Pastorino including associated specialties, affiliations and a list of published articles.
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52
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4223
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Recent Articles
1.
Novelli F, Yoshikawa Y, Vitto V, Modesti L, Minaai M, Pastorino S, et al.
Proc Natl Acad Sci U S A
. 2024 Jul;
121(29):e2405231121.
PMID: 38990952
We report that ~1.8% of all mesothelioma patients and 4.9% of those younger than 55, carry rare germline variants of the BRCA1 associated RING domain 1 ( gene that were...
2.
Mukthavaram R, Jiang P, Pastorino S, Nomura N, Lin F, Kesari S
Bioelectron Med
. 2024 Apr;
10(1):10.
PMID: 38594769
Background: Glioblastoma (GBM) presents as an aggressive brain cancer, notorious for its recurrence and resistance to conventional treatments. This study aimed to assess the efficacy of the EMulate Therapeutics Voyager®,...
3.
Suarez J, Novelli F, Goto K, Ehara M, Steele M, Kim J, et al.
Proc Natl Acad Sci U S A
. 2023 Sep;
120(39):e2307999120.
PMID: 37729199
Asbestos is the main cause of malignant mesothelioma. Previous studies have linked asbestos-induced mesothelioma to the release of HMGB1 from the nucleus to the cytoplasm, and from the cytoplasm to...
4.
Bononi A, Wang Q, Zolondick A, Bai F, Steele-Tanji M, Suarez J, et al.
Proc Natl Acad Sci U S A
. 2023 Jan;
120(4):e2217840120.
PMID: 36656861
is a powerful tumor suppressor gene characterized by haplo insufficiency. Individuals carrying germline mutations often develop mesothelioma, an aggressive malignancy of the serosal layers covering the lungs, pericardium, and abdominal...
5.
Carbone M, Pass H, Ak G, Alexander Jr H, Baas P, Baumann F, et al.
J Thorac Oncol
. 2022 Apr;
17(7):873-889.
PMID: 35462085
The most common malignancies that develop in carriers of BAP1 germline mutations include diffuse malignant mesothelioma, uveal and cutaneous melanoma, renal cell carcinoma, and less frequently, breast cancer, several types...
6.
BAP1 forms a trimer with HMGB1 and HDAC1 that modulates gene × environment interaction with asbestos
Novelli F, Bononi A, Wang Q, Bai F, Patergnani S, Kricek F, et al.
Proc Natl Acad Sci U S A
. 2021 Nov;
118(48).
PMID: 34815344
Carriers of heterozygous germline mutations () are affected by the "BAP1 cancer syndrome." Although they can develop almost any cancer type, they are unusually susceptible to asbestos carcinogenesis and mesothelioma....
7.
Bononi A, Goto K, Ak G, Yoshikawa Y, Emi M, Pastorino S, et al.
Proc Natl Acad Sci U S A
. 2020 Dec;
117(52):33466-33473.
PMID: 33318203
Rare biallelic gene mutations cause Bloom syndrome. Whether heterozygous germline mutations () cause human cancer remains unclear. We sequenced the germline DNA of 155 mesothelioma patients (33 familial and 122...
8.
Xue J, Patergnani S, Giorgi C, Suarez J, Goto K, Bononi A, et al.
Proc Natl Acad Sci U S A
. 2020 Oct;
117(41):25543-25552.
PMID: 32999071
Asbestos causes malignant transformation of primary human mesothelial cells (HM), leading to mesothelioma. The mechanisms of asbestos carcinogenesis remain enigmatic, as exposure to asbestos induces HM death. However, some asbestos-exposed...
9.
Napolitano A, Antoine D, Pellegrini L, Baumann F, Pagano I, Pastorino S, et al.
Clin Cancer Res
. 2020 Mar;
26(6):1529.
PMID: 32169964
No abstract available.
10.
Bertino P, Premeaux T, Fujita T, Haun B, Marciel M, Hoffmann F, et al.
Oncoimmunology
. 2019 Aug;
8(8):1601482.
PMID: 31413910
Galectin-9 has emerged as a promising biological target for cancer immunotherapy due to its role as a regulator of macrophage and T-cell differentiation. In addition, its expression in tumor cells...