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Michael Merchant

Explore the profile of Michael Merchant including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 39
Citations 1352
Followers 0
Related Specialties
Biochemistry
Nephrology
Neurology
Top 10 Co-Authors
Jon B Klein
Jian Cai
Jon Klein
Daniel W Wilkey
Shesh N Rai
Craig J McClain
Daniel Wilkey
William M Pierce
Madhavi J Rane
Rukhsana Sultana
Published In
J Proteomics Bioinform
Nephrol Dial Transplant
J Am Soc Nephrol
Kidney Int Rep
J Biol Chem
Affiliations
Soon will be listed here.
Recent Articles
1.
Ileum Proteomics Identifies Distinct Pathways Associated with Different Dietary Doses of Copper-Fructose Interactions: Implications for the Gut-Liver Axis and MASLD
Xu M, Li M, Benz F, Merchant M, McClain C, Song M
Nutrients . 2024 Jul; 16(13). PMID: 38999831
The interactions of different dietary doses of copper with fructose contribute to the development of metabolic dysfunction-associated steatotic liver disease (MASLD) via the gut-liver axis. The underlying mechanisms remain elusive....
2.
Site-Specific Identification of Protein S-Acylation by IodoTMT0 Labeling and Immobilized Anti-TMT Antibody Resin Enrichment
Cai J, Song M, Li M, Merchant M, Benz F, McClain C, et al.
J Proteome Res . 2023 Dec; 23(2):673-683. PMID: 38157263
Protein S-acylation is a reversible post-translational modification (PTM). It is present on diverse proteins and has important roles in regulating protein function. Aminolysis with hydroxylamine is widely used in the...
3.
Increased expression of phosphodiesterase 4 in activated hepatic stellate cells promotes cytoskeleton remodeling and cell migration
Elnagdy M, Wang Y, Rodriguez W, Zhang J, Bauer P, Wilkey D, et al.
J Pathol . 2023 Sep; 261(3):361-371. PMID: 37735782
Activation and transdifferentiation of hepatic stellate cells (HSC) into migratory myofibroblasts is a key process in liver fibrogenesis. Cell migration requires an active remodeling of the cytoskeleton, which is a...
4.
Multiomics Analysis of Plasma Proteomics and Metabolomics of Steroid Resistance in Childhood Nephrotic Syndrome Using a "Patient-Specific" Approach
Bhayana S, Zhao Y, Merchant M, Cummins T, Dougherty J, Kamigaki Y, et al.
Kidney Int Rep . 2023 Jun; 8(6):1239-1254. PMID: 37284673
Introduction: Nephrotic syndrome (NS) occurs commonly in children with glomerular disease and glucocorticoids (GCs) are the mainstay treatment. Steroid resistant NS (SRNS) develops in 15% to 20% of children, increasing...
5.
MK2 nonenzymatically promotes nuclear translocation of caspase-3 and resultant apoptosis
Del Rosario O, Suresh K, Kallem M, Singh G, Shah A, Zheng L, et al.
Am J Physiol Lung Cell Mol Physiol . 2023 Mar; 324(5):L700-L711. PMID: 36976920
We have previously identified mitogen-activated protein kinase-activated protein kinase 2 (MK2) is required for caspase-3 nuclear translocation in the execution of apoptosis; however, little is known of the underlying mechanisms....
6.
Tumor MK2 transcript levels are associated with improved response to chemotherapy and patient survival in non-small cell lung cancer
Suresh K, Del Rosario O, Kallem M, Singh G, Shah A, Zheng L, et al.
Physiol Genomics . 2023 Mar; 55(4):168-178. PMID: 36878491
Non-small cell lung cancers (NSCLCs) demonstrate intrinsic resistance to cell death, even after chemotherapy. Previous work suggested defective nuclear translocation of active caspase-3 in observed resistance to cell death. We...
7.
Impact of DNA Geometry and Scoring on Monte Carlo Track-Structure Simulations of Initial Radiation-Induced Damage
Bertolet A, Ramos-Mendez J, McNamara A, Yoo D, Ingram S, Henthorn N, et al.
Radiat Res . 2022 Jun; 198(3):207-220. PMID: 35767729
Track structure Monte Carlo simulations are a useful tool to investigate the damage induced to DNA by ionizing radiation. These simulations usually rely on simplified geometrical representations of the DNA...
8.
Towards harmonizing clinical linear energy transfer (LET) reporting in proton radiotherapy: a European multi-centric study
Hahn C, Oden J, Dasu A, Vestergaard A, Jensen M, Sokol O, et al.
Acta Oncol . 2021 Oct; 61(2):206-214. PMID: 34686122
Background: Clinical data suggest that the relative biological effectiveness (RBE) in proton therapy (PT) varies with linear energy transfer (LET). However, LET calculations are neither standardized nor available in clinical...
9.
In vivo deep network tracing reveals phosphofructokinase-mediated coordination of biosynthetic pathway activity in the myocardium
Fulghum K, Audam T, Lorkiewicz P, Zheng Y, Merchant M, Cummins T, et al.
J Mol Cell Cardiol . 2021 Sep; 162:32-42. PMID: 34487754
Glucose metabolism comprises numerous amphibolic metabolites that provide precursors for not only the synthesis of cellular building blocks but also for ATP production. In this study, we tested how phosphofructokinase-1...
10.
Exosome-Like Nanoparticles From GG Protect Against Alcohol-Associated Liver Disease Through Intestinal Aryl Hydrocarbon Receptor in Mice
Gu Z, Li F, Liu Y, Jiang M, Zhang L, He L, et al.
Hepatol Commun . 2021 May; 5(5):846-864. PMID: 34027273
Alcohol-associated liver disease (ALD) is a major cause of mortality. Gut barrier dysfunction-induced bacterial translocation and endotoxin release contribute to the pathogenesis of ALD. Probiotic GG (LGG) is known to...