Michael MacLean
Overview
Explore the profile of Michael MacLean including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
258
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Recent Articles
1.
Marola O, MacLean M, Cossette T, Diemler C, Hewes A, Reagan A, et al.
Mol Neurodegener
. 2025 Jan;
20(1):8.
PMID: 39833899
Background: Age is the principal risk factor for neurodegeneration in both the retina and brain. The retina and brain share many biological properties; thus, insights into retinal aging and degeneration...
2.
Diemler C, MacLean M, Heuer S, Hewes A, Marola O, Libby R, et al.
Front Aging Neurosci
. 2024 Jul;
16:1396443.
PMID: 39015474
In recent years, microglia have been highlighted for playing integral roles in neurodegenerative diseases, like glaucoma. To better understand the role of microglia during chronic ocular hypertension, we depleted microglia...
3.
Andersh K, MacLean M, Howell G, Libby R
bioRxiv
. 2024 Jun;
PMID: 38854045
Glaucoma is a neurodegenerative disease that leads to the death of retinal ganglion cells (RGCs). A growing body of literature suggests a role for neuroinflammation in RGC death after glaucoma-relevant...
4.
Marola O, MacLean M, Cossette T, Diemler C, Hewes A, Reagan A, et al.
bioRxiv
. 2024 Apr;
PMID: 38659747
Background: Age is the principal risk factor for neurodegeneration in both the retina and brain. The retina and brain share many biological properties; thus, insights into retinal aging and degeneration...
5.
Diemler C, MacLean M, Heuer S, Hewes A, Marola O, Libby R, et al.
bioRxiv
. 2024 Mar;
PMID: 38496398
In recent years, microglia have been highlighted for playing integral roles in neurodegenerative diseases, like glaucoma. To better understand the role of microglia during chronic ocular hypertension, we depleted microglia...
6.
Telpoukhovskaia M, Murdy T, Marola O, Charland K, MacLean M, Luquez T, et al.
Alzheimers Dement (N Y)
. 2024 Mar;
10(1):e12458.
PMID: 38469553
Introduction: In September 2022, The Jackson Laboratory Center for Alzheimer's and Dementia Research (JAX CADR) hosted a workshop with leading researchers in the Alzheimer's disease and related dementias (ADRD) field....
7.
Davern M, Donlon N, OConnell F, Gaughan C, ODonovan C, McGrath J, et al.
J Cancer Res Clin Oncol
. 2022 Nov;
149(8):5377-5395.
PMID: 36445478
Aim: Use of immune checkpoint blockade to enhance T cell-mediated immunity within the hostile tumour microenvironment (TME) is an attractive approach in oesophageal adenocarcinoma (OAC). This study explored the effects...
8.
Davern M, Donlon N, OConnell F, Gaughan C, ODonovan C, Habash M, et al.
Cancer Immunol Immunother
. 2022 Jun;
72(1):55-71.
PMID: 35708739
Tumour acidosis contributes to cancer progression by inhibiting anti-tumour immunity. However, the effect of acidosis on anti-tumour T cell phenotypes in oesophageal adenocarcinoma (OAC) is unknown. Therefore, this study investigated...
9.
MacLean M, Lopez-Diez R, Vasquez C, Gugger P, Schmidt A
Commun Biol
. 2022 Mar;
5(1):177.
PMID: 35228715
Amyotrophic lateral sclerosis (ALS) is an incurable disease characterized by proteinaceous aggregate accumulation and neuroinflammation culminating in rapidly progressive lower and upper motor neuron death. To interrogate cell-intrinsic and inter-cell...
10.
Senatus L, MacLean M, Arivazhagan L, Egana-Gorrono L, Lopez-Diez R, Manigrasso M, et al.
Immunometabolism
. 2021 Jun;
3(3).
PMID: 34178389
Fundamental modulation of energy metabolism in immune cells is increasingly being recognized for the ability to impart important changes in cellular properties. In homeostasis, cells of the innate immune system,...