Michael M Wang
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Explore the profile of Michael M Wang including associated specialties, affiliations and a list of published articles.
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86
Citations
1307
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Recent Articles
1.
Cartee N, Lee S, Wu E, Sukpraphrute R, Sukpraphrute C, Greenbaum J, et al.
J Biol Chem
. 2025 Jan;
301(3):108224.
PMID: 39864627
Stereotyped mutations in NOTCH3 drive CADASIL, the leading inherited cause of stroke and vascular dementia. The vast majority of these mutations result in alterations in the number of cysteines in...
2.
Romay M, Knutsen R, Ma F, Mompeon A, Hernandez G, Salvador J, et al.
J Clin Invest
. 2023 Nov;
134(2).
PMID: 38015629
Vascular aging affects multiple organ systems, including the brain, where it can lead to vascular dementia. However, a concrete understanding of how aging specifically affects the brain vasculature, along with...
3.
Chopp L, Zhu X, Gao Y, Nie J, Singh J, Kumar P, et al.
Sci Immunol
. 2023 Nov;
8(89):eadi9066.
PMID: 37948511
How CD4 lineage gene expression is initiated in differentiating thymocytes remains poorly understood. Here, we show that the paralog transcription factors Zfp281 and Zfp148 control both this process and cytokine...
4.
Meschia J, Worrall B, Elahi F, Ross O, Wang M, Goldstein E, et al.
Stroke
. 2023 Aug;
54(10):e452-e464.
PMID: 37602377
Lacunar infarcts and vascular dementia are important phenotypic characteristics of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, the most common inherited cerebral small vessel disease. Individuals with the...
5.
Lee S, Gasche M, Burrows C, Kondepudi A, Zhang X, Wang M
Sci Rep
. 2023 Jun;
13(1):9156.
PMID: 37280231
Antibodies raised in peptide-immunized rabbits have been used in biological research for decades. Although there has been wide implementation of this approach, specific proteins are occasionally difficult to target for...
6.
Lee S, Zhang X, Wu E, Sukpraphrute R, Sukpraphrute C, Ye A, et al.
J Biol Chem
. 2023 May;
299(6):104838.
PMID: 37209821
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a cerebral small vessel disease that results from mutations in NOTCH3. How mutations in NOTCH3 ultimately result in disease...
7.
Surge of neurophysiological coupling and connectivity of gamma oscillations in the dying human brain
Xu G, Mihaylova T, Li D, Tian F, Farrehi P, Parent J, et al.
Proc Natl Acad Sci U S A
. 2023 May;
120(19):e2216268120.
PMID: 37126719
The brain is assumed to be hypoactive during cardiac arrest. However, animal models of cardiac and respiratory arrest demonstrate a surge of gamma oscillations and functional connectivity. To investigate whether...
8.
Elahi F, Wang M, Meschia J
Stroke
. 2023 Feb;
54(3):648-660.
PMID: 36848423
Cerebral small vessel disease (CSVD) has emerged as a common factor driving age-dependent diseases, including stroke and dementia. CSVD-related dementia will affect a growing fraction of the aging population, requiring...
9.
Lee S, Kondepudi A, Young K, Zhang X, Cartee N, Chen J, et al.
PLoS One
. 2023 Feb;
18(2):e0281094.
PMID: 36753487
The most common inherited cause of vascular dementia and stroke, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), is caused by mutations in NOTCH3. Post-translationally altered NOTCH3 accumulates...
10.
Glynos N, Carter L, Lee S, Kim Y, Kennedy R, Mashour G, et al.
Sci Rep
. 2023 Jan;
13(1):280.
PMID: 36609666
Indolethylamine N-methyltransferase (INMT) is a transmethylation enzyme that utilizes the methyl donor S-adenosyl-L-methionine to transfer methyl groups to amino groups of small molecule acceptor compounds. INMT is best known for...