Michael L Risner
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Explore the profile of Michael L Risner including associated specialties, affiliations and a list of published articles.
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32
Citations
451
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Recent Articles
1.
Risner M, Ribeiro M, McGrady N, Kagitapalli B, Chamling X, Zack D, et al.
Cell Commun Signal
. 2023 Oct;
21(1):305.
PMID: 37904133
Background: Cell-to-cell communication is vital for tissues to respond, adapt, and thrive in the prevailing milieu. Several mechanisms mediate intercellular signaling, including tunneling nanotubes, gap junctions, and extracellular vesicles (EV)....
2.
Boal A, McGrady N, Holden J, Risner M, Calkins D
Front Neurosci
. 2023 Apr;
17:1142668.
PMID: 37051140
Introduction: Identification of early adaptive and maladaptive neuronal stress responses is an important step in developing targeted neuroprotective therapies for degenerative disease. In glaucoma, retinal ganglion cells (RGCs) and their...
3.
McGrady N, Boal A, Risner M, Taiel M, Sahel J, Calkins D
Mol Ther
. 2023 Apr;
31(7):2005-2013.
PMID: 37016579
Lenadogene nolparvovec (GS010) was developed to treat a point mutation in mitochondrial ND4 that causes Leber hereditary optic neuropathy. GS010 delivers human cDNA encoding wild-type ND4 packaged into an rAAV2/2...
4.
Boal A, McGrady N, Chamling X, Kagitapalli B, Zack D, Calkins D, et al.
Transl Vis Sci Technol
. 2023 Apr;
12(4):1.
PMID: 37010860
Purpose: Axons depend on long-range transport of proteins and organelles which increases susceptibility to metabolic stress in disease. The axon initial segment (AIS) is particularly vulnerable due to the high...
5.
Esteban-Linares A, Zhang X, Lee H, Risner M, Weiss S, Xu Y, et al.
Lab Chip
. 2023 Mar;
23(9):2193-2205.
PMID: 36891773
Perforated microelectrode arrays (pMEAs) have become essential tools for retinal electrophysiological studies. pMEAs increase the nutrient supply to the explant and alleviate the accentuated curvature of the retina, allowing for...
6.
Croteau L, Risner M, Wareham L, McGrady N, Chamling X, Zack D, et al.
Cells
. 2022 Oct;
11(20).
PMID: 36291110
Cell replacement therapies may be key in achieving functional recovery in neurodegenerative optic neuropathies diseases such as glaucoma. One strategy that holds promise in this regard is the use of...
7.
McGrady N, Holden J, Ribeiro M, Boal A, Risner M, Calkins D
Brain Commun
. 2022 Oct;
4(5):fcac251.
PMID: 36267329
Optic neuropathies are characterized by degeneration of retinal ganglion cell axonal projections to the brain, including acute conditions like optic nerve trauma and progressive conditions such as glaucoma. Despite different...
8.
Boal A, McGrady N, Risner M, Calkins D
Front Cell Neurosci
. 2022 Aug;
16:966425.
PMID: 35990894
Neuronal type-specific physiologic heterogeneity can be driven by both extrinsic and intrinsic mechanisms. In retinal ganglion cells (RGCs), which carry visual information from the retina to central targets, evidence suggests...
9.
Holden J, Al Awamlh S, Croteau L, Boal A, Rex T, Risner M, et al.
Int J Mol Sci
. 2022 Mar;
23(6).
PMID: 35328488
The nitric oxide-guanylyl cyclase-1-cyclic guanylate monophosphate (NO-GC-1-cGMP) pathway is integral to the control of vascular tone and morphology. Mice lacking the alpha catalytic domain of guanylate cyclase () develop retinal...
10.
Risner M, Pasini S, McGrady N, Calkins D
Mol Neurobiol
. 2022 Jan;
59(3):1366-1380.
PMID: 34984584
The BCL-2 (B-cell lymphoma-2) family of proteins contributes to mitochondrial-based apoptosis in models of neurodegeneration, including glaucomatous optic neuropathy (glaucoma), which degrades the retinal ganglion cell (RGC) axonal projection to...