Michael L Hutton
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Explore the profile of Michael L Hutton including associated specialties, affiliations and a list of published articles.
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41
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3358
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Recent Articles
1.
Kielbasa W, Goldsmith P, Donnelly K, Nuthall H, Shcherbinin S, Fleisher A, et al.
Alzheimers Dement (N Y)
. 2025 Jan;
10(4):e70020.
PMID: 39748851
Introduction: The aggregation and spread of hyperphosphorylated, pathological tau in the human brain is hypothesized to play a key role in Alzheimer's disease (AD) as well as other neurogenerative tauopathies....
2.
Stephen T, Tamagnini F, Piegsa J, Sung K, Harvey J, Oliver-Evans A, et al.
Sci Rep
. 2019 Oct;
9(1):14837.
PMID: 31619689
Alzheimer's disease (AD)-associated synaptic dysfunction drives the progression of pathology from its earliest stages. Amyloid β (Aβ) species, both soluble and in plaque deposits, have been causally related to the...
3.
Corriveau R, Koroshetz W, Gladman J, Jeon S, Babcock D, Bennett D, et al.
Neurology
. 2017 Nov;
89(23):2381-2391.
PMID: 29117955
Goal 1 of the National Plan to Address Alzheimer's Disease is to prevent and effectively treat Alzheimer disease and Alzheimer disease-related dementias by 2025. To help inform the research agenda...
4.
Jackson J, Witton J, Johnson J, Ahmed Z, Ward M, Randall A, et al.
Cell Rep
. 2017 Mar;
18(13):3063-3068.
PMID: 28355559
Synapse loss is a key feature of dementia, but it is unclear whether synaptic dysfunction precedes degenerative phases of the disease. Here, we show that even before any decrease in...
5.
Falcon B, Cavallini A, Angers R, Glover S, Murray T, Barnham L, et al.
J Biol Chem
. 2014 Nov;
290(2):1049-65.
PMID: 25406315
Intracellular Tau inclusions are a pathological hallmark of several neurodegenerative diseases, collectively known as the tauopathies. They include Alzheimer disease, tangle-only dementia, Pick disease, argyrophilic grain disease, chronic traumatic encephalopathy,...
6.
Phillips E, Croft C, Kurbatskaya K, ONeill M, Hutton M, Hanger D, et al.
Biochem Soc Trans
. 2014 Sep;
42(5):1321-5.
PMID: 25233410
Increased production of amyloid β-peptide (Aβ) and altered processing of tau in Alzheimer's disease (AD) are associated with synaptic dysfunction, neuronal death and cognitive and behavioural deficits. Neuroinflammation is also...
7.
Siemers E, Dean R, DeMattos R, Hutton M, Blennow K, Shaw L, et al.
Acta Neuropathol
. 2014 Aug;
128(4):609-10.
PMID: 25120192
No abstract available.
8.
Montine T, Koroshetz W, Babcock D, Dickson D, Galpern W, Glymour M, et al.
Neurology
. 2014 Aug;
83(9):851-60.
PMID: 25080517
The National Alzheimer's Project Act, signed into law in 2011, mandates a National Plan to Address Alzheimer's Disease that is updated annually. In the Plan, the term Alzheimer disease includes...
9.
Ahmed Z, Cooper J, Murray T, Garn K, McNaughton E, Clarke H, et al.
Acta Neuropathol
. 2014 Feb;
127(5):667-83.
PMID: 24531916
Intracellular inclusions composed of hyperphosphorylated filamentous tau are a hallmark of Alzheimer's disease, progressive supranuclear palsy, Pick's disease and other sporadic neurodegenerative tauopathies. Recent in vitro and in vivo studies...
10.
Baker M, Strongosky A, Sanchez-Contreras M, Yang S, Ferguson W, Calne D, et al.
Neurogenetics
. 2013 Oct;
15(1):23-30.
PMID: 24135862
Idiopathic basal ganglia calcification (IBGC) is characterized by bilateral calcification of the basal ganglia associated with a spectrum of neuropsychiatric and motor syndromes. In this study, we set out to...