Michael L Gonzales
Overview
Explore the profile of Michael L Gonzales including associated specialties, affiliations and a list of published articles.
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15
Citations
1689
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0
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Recent Articles
1.
Mayer S, Chen J, Velmeshev D, Mayer A, Eze U, Bhaduri A, et al.
Neuron
. 2019 Feb;
102(1):143-158.e7.
PMID: 30770253
In the developing human neocortex, progenitor cells generate diverse cell types prenatally. Progenitor cells and newborn neurons respond to signaling cues, including neurotransmitters. While single-cell RNA sequencing has revealed cellular...
2.
Ramalingam N, Fowler B, Szpankowski L, Leyrat A, Hukari K, Maung M, et al.
Front Bioeng Biotechnol
. 2017 Mar;
5:11.
PMID: 28299310
[This corrects the article on p. 70 in vol. 4, PMID: 27709111.].
3.
Ramalingam N, Fowler B, Szpankowski L, Leyrat A, Hukari K, Maung M, et al.
Front Bioeng Biotechnol
. 2016 Oct;
4:70.
PMID: 27709111
The study of single cells has evolved over the past several years to include expression and genomic analysis of an increasing number of single cells. Several studies have demonstrated wide...
4.
Szulwach K, Chen P, Wang X, Wang J, Weaver L, Gonzales M, et al.
PLoS One
. 2015 Aug;
10(8):e0135007.
PMID: 26302375
Somatic mosaicism occurs throughout normal development and contributes to numerous disease etiologies, including tumorigenesis and neurological disorders. Intratumor genetic heterogeneity is inherent to many cancers, creating challenges for effective treatments....
5.
Buenrostro J, Wu B, Litzenburger U, Ruff D, Gonzales M, Snyder M, et al.
Nature
. 2015 Jun;
523(7561):486-90.
PMID: 26083756
Cell-to-cell variation is a universal feature of life that affects a wide range of biological phenomena, from developmental plasticity to tumour heterogeneity. Although recent advances have improved our ability to...
6.
Yasui D, Gonzales M, Aflatooni J, Crary F, Hu D, Gavino B, et al.
Hum Mol Genet
. 2013 Dec;
23(9):2447-58.
PMID: 24352790
Mutations in MECP2 cause the neurodevelopmental disorder Rett syndrome (RTT OMIM 312750). Alternative inclusion of MECP2/Mecp2 exon 1 with exons 3 and 4 encodes MeCP2-e1 or MeCP2-e2 protein isoforms with...
7.
Powell W, Coulson R, Gonzales M, Crary F, Wong S, Adams S, et al.
Proc Natl Acad Sci U S A
. 2013 Aug;
110(34):13938-43.
PMID: 23918391
Prader-Willi syndrome (PWS) and Angelman syndrome (AS) are oppositely imprinted autism-spectrum disorders with known genetic bases, but complex epigenetic mechanisms underlie their pathogenesis. The PWS/AS locus on 15q11-q13 is regulated...
8.
Gonzales M, Adams S, Dunaway K, LaSalle J
Mol Cell Biol
. 2012 May;
32(14):2894-903.
PMID: 22615490
Mutations in the gene encoding methyl-CpG-binding protein 2 (MeCP2) lead to disrupted neuronal function and can cause the neurodevelopmental disorder Rett syndrome. MeCP2 is a transcriptional regulator that binds to...
9.
Singleton M, Gonzales M, Leung K, Yasui D, Schroeder D, Dunaway K, et al.
Neurobiol Dis
. 2011 Mar;
43(1):190-200.
PMID: 21420494
Mutations in MECP2, encoding methyl CpG binding protein 2, cause the neurodevelopmental disorder Rett syndrome. MeCP2 is an abundant nuclear protein that binds to chromatin and modulates transcription in response...
10.
Gonzales M, LaSalle J
Curr Psychiatry Rep
. 2010 Apr;
12(2):127-34.
PMID: 20425298
Methyl CpG binding protein-2 (MeCP2) is an essential epigenetic regulator in human brain development. Rett syndrome, the primary disorder caused by mutations in the X-linked MECP2 gene, is characterized by...