Michael J Tuvim
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Explore the profile of Michael J Tuvim including associated specialties, affiliations and a list of published articles.
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54
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2259
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Recent Articles
1.
Wang Y, Kulkarni V, Garcia J, Leiva-Juarez M, Goldblatt D, Gulraiz F, et al.
PLoS Pathog
. 2023 Sep;
19(9):e1011138.
PMID: 37695784
Pneumonia is a worldwide threat, making discovery of novel means to combat lower respiratory tract infection an urgent need. Manipulating the lungs' intrinsic host defenses by therapeutic delivery of certain...
2.
Wang Y, Kulkarni V, Garcia J, Leiva-Juarez M, Goldblatt D, Gulraiz F, et al.
bioRxiv
. 2023 Jan;
PMID: 36711510
Author Summary: Pneumonia is a major cause of death worldwide. Increasing antibiotic resistance and expanding immunocompromised populations continue to enhance the clinical urgency to find new strategies to prevent and...
3.
Goldblatt D, Valverde Ha G, Wali S, Kulkarni V, Longmire M, Jaramillo A, et al.
Front Pharmacol
. 2022 Sep;
13:833380.
PMID: 36105216
Allergic asthma is a chronic inflammatory respiratory disease associated with eosinophilic infiltration, increased mucus production, airway hyperresponsiveness, and airway remodeling. Epidemiologic data reveal that the prevalence of allergic sensitization and...
4.
Lai Y, Tuvim M, Leitz J, Peters J, Pfuetzner R, Esquivies L, et al.
Front Pharmacol
. 2022 Jul;
13:891041.
PMID: 35814209
The so-called primary interface between the SNARE complex and synaptotagmin-1 (Syt1) is essential for Ca-triggered neurotransmitter release in neuronal synapses. The interacting residues of the primary interface are conserved across...
5.
Hoang O, Ermund A, Jaramillo A, Fakih D, French C, Flores J, et al.
Am J Respir Crit Care Med
. 2022 Jul;
206(9):1081-1095.
PMID: 35776514
MUC5AC (mucin 5AC, oligomeric gel-forming) and MUC5B (mucin 5B, oligomeric gel-forming) are the predominant secreted polymeric mucins in mammalian airways. They contribute differently to the pathogenesis of various muco-obstructive and...
6.
Hernandez B, Cain M, Lynch A, Flores J, Tuvim M, Dickey B, et al.
Am J Respir Cell Mol Biol
. 2022 Jun;
67(3):389-401.
PMID: 35679221
The lung epithelium forms the first barrier against respiratory pathogens and noxious chemicals; however, little is known about how more than 90% of this barrier, made of AT1 (alveolar type...
7.
Lai Y, Fois G, Flores J, Tuvim M, Zhou Q, Yang K, et al.
Nature
. 2022 Mar;
603(7903):949-956.
PMID: 35322233
Membrane fusion triggered by Ca is orchestrated by a conserved set of proteins to mediate synaptic neurotransmitter release, mucin secretion and other regulated exocytic processes. For neurotransmitter release, the Ca...
8.
Johnston S, Goldblatt D, Evans S, Tuvim M, Dickey B
Front Physiol
. 2021 Dec;
12:749077.
PMID: 34899381
Besides providing an essential protective barrier, airway epithelial cells directly sense pathogens and respond defensively. This is a frontline component of the innate immune system with specificity for different pathogen...
9.
Wali S, Flores J, Jaramillo A, Goldblatt D, Garcia J, Tuvim M, et al.
Am J Respir Cell Mol Biol
. 2020 Aug;
63(6):758-766.
PMID: 32853024
Viral pneumonias remain global health threats, as exemplified in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, requiring novel treatment strategies both early and late in the disease process....
10.
Danahay H, Fox R, Lilley S, Charlton H, Adley K, Christie L, et al.
FASEB Bioadv
. 2020 Aug;
2(8):464-477.
PMID: 32821878
The calcium-activated chloride channel (CaCC) TMEM16A enables chloride secretion across several transporting epithelia, including in the airways. Additional roles for TMEM16A have been proposed, which include regulating mucus production and...