Michael J T Stubbington
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Explore the profile of Michael J T Stubbington including associated specialties, affiliations and a list of published articles.
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26
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3922
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Recent Articles
1.
Hurtado J, Rogers T, Jaffe D, Adams B, Bangaru S, Garcia E, et al.
Cell Rep
. 2024 Jun;
43(6):114307.
PMID: 38848216
The development of vaccines and therapeutics that are broadly effective against known and emergent coronaviruses is an urgent priority. We screened the circulating B cell repertoires of COVID-19 survivors and...
2.
Mielczarek O, Rogers C, Zhan Y, Matheson L, Stubbington M, Schoenfelder S, et al.
Cell Rep
. 2023 Sep;
42(9):113074.
PMID: 37676766
To produce a diverse antibody repertoire, immunoglobulin heavy-chain (Igh) loci undergo large-scale alterations in structure to facilitate juxtaposition and recombination of spatially separated variable (V), diversity (D), and joining (J)...
3.
Hurtado J, Rogers T, Jaffe D, Adams B, Bangaru S, Garcia E, et al.
bioRxiv
. 2023 Apr;
PMID: 37034676
Development of vaccines and therapeutics that are broadly effective against known and emergent coronaviruses is an urgent priority. Current strategies for developing pan-coronavirus countermeasures have largely focused on the receptor...
4.
McMurray J, von Borstel A, Taher T, Syrimi E, Taylor G, Sharif M, et al.
Cell Rep
. 2022 May;
39(8):110858.
PMID: 35613583
γδ T cells are generally considered innate-like lymphocytes, however, an "adaptive-like" γδ compartment has now emerged. To understand transcriptional regulation of adaptive γδ T cell immunobiology, we combined single-cell transcriptomics,...
5.
Schattgen S, Guion K, Crawford J, Souquette A, Martinez Barrio A, Stubbington M, et al.
Nat Biotechnol
. 2021 Aug;
40(1):54-63.
PMID: 34426704
Links between T cell clonotypes, as defined by T cell receptor (TCR) sequences, and phenotype, as reflected in gene expression (GEX) profiles, surface protein expression and peptide:major histocompatibility complex binding,...
6.
Baizan-Edge A, Stubbs B, Stubbington M, Bolland D, Tabbada K, Andrews S, et al.
Cell Rep
. 2021 Jul;
36(2):109349.
PMID: 34260907
Generation of the primary antibody repertoire requires V(D)J recombination of hundreds of gene segments in the immunoglobulin heavy chain (Igh) locus. The role of interleukin-7 receptor (IL-7R) signaling in Igh...
7.
Darby C, Stubbington M, Marks P, Martinez Barrio A, Fiddes I
Bioinformatics
. 2020 Apr;
36(12):3905-3906.
PMID: 32330223
Summary: Bulk RNA sequencing studies have demonstrated that human leukocyte antigen (HLA) genes may be expressed in a cell type-specific and allele-specific fashion. Single-cell gene expression assays have the potential...
8.
Popescu D, Botting R, Stephenson E, Green K, Webb S, Jardine L, et al.
Nature
. 2019 Oct;
574(7778):365-371.
PMID: 31597962
Definitive haematopoiesis in the fetal liver supports self-renewal and differentiation of haematopoietic stem cells and multipotent progenitors (HSC/MPPs) but remains poorly defined in humans. Here, using single-cell transcriptome profiling of...
9.
Lindeman I, Stubbington M
Methods Mol Biol
. 2019 Feb;
1935:223-249.
PMID: 30758830
In this chapter, we describe TraCeR and BraCeR, our computational tools for reconstruction of paired full-length antigen receptor sequences and clonality inference from single-cell RNA-seq (scRNA-seq) data. In brief, TraCeR...
10.
Vento-Tormo R, Efremova M, Botting R, Turco M, Vento-Tormo M, Meyer K, et al.
Nature
. 2018 Nov;
563(7731):347-353.
PMID: 30429548
During early human pregnancy the uterine mucosa transforms into the decidua, into which the fetal placenta implants and where placental trophoblast cells intermingle and communicate with maternal cells. Trophoblast-decidual interactions...