Michael J Soth
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Explore the profile of Michael J Soth including associated specialties, affiliations and a list of published articles.
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11
Citations
117
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Recent Articles
1.
Yuan X, Hao X, Chan H, Zhao N, Pedroza D, Liu F, et al.
JCI Insight
. 2024 Sep;
9(20).
PMID: 39287984
Tumor-associated neutrophils (TANs) have been shown to promote immunosuppression and tumor progression, and a high TAN frequency predicts poor prognosis in triple-negative breast cancer (TNBC). Dysregulation of CREB-binding protein (CBP)/P300...
2.
Yuan X, Hao X, Chan H, Zhao N, Pedroza D, Liu F, et al.
bioRxiv
. 2024 May;
PMID: 38712292
Tumor-associated neutrophils (TANs) have been shown to promote immunosuppression and tumor progression, and a high TAN frequency predicts poor prognosis in triple-negative breast cancer (TNBC). Dysregulation of CREB binding protein...
3.
Le K, Soth M, Cross J, Liu G, Ray W, Ma J, et al.
J Med Chem
. 2023 Jul;
66(14):9954-9971.
PMID: 37436942
Chemotherapy-induced peripheral neuropathy (CIPN) is a major unmet medical need with limited treatment options. Despite different mechanisms of action, diverse chemotherapeutics can cause CIPN through a converged pathway─an active axon...
4.
Fiskus W, Mill C, Birdwell C, Davis J, Das K, Boettcher S, et al.
Blood Cancer J
. 2023 Apr;
13(1):53.
PMID: 37055414
Monotherapy with Menin inhibitor (MI), e.g., SNDX-5613, induces clinical remissions in patients with relapsed/refractory AML harboring MLL1-r or mtNPM1, but most patients either fail to respond or eventually relapse. Utilizing...
5.
Hamilton M, Mseeh F, McAfoos T, Leonard P, Reyna N, Harris A, et al.
J Med Chem
. 2021 Jul;
64(15):11302-11329.
PMID: 34292726
Indoleamine 2,3-dioxygenase 1 (IDO1), a heme-containing enzyme that mediates the rate-limiting step in the metabolism of l-tryptophan to kynurenine, has been widely explored as a potential immunotherapeutic target in oncology....
6.
Ma J, Goodwani S, Acton P, Buggia-Prevot V, Kesler S, Jamal I, et al.
Pain
. 2021 Apr;
162(10):2599-2612.
PMID: 33872235
Chemotherapy-induced peripheral neuropathy (CIPN) and chemotherapy-induced cognitive impairments (CICI) are common, often severe neurotoxic side effects of cancer treatment that greatly reduce quality of life of cancer patients and survivors....
7.
Soth M, Le K, Francesco M, Hamilton M, Liu G, Burke J, et al.
J Med Chem
. 2020 Oct;
63(21):12957-12977.
PMID: 33118821
Inhibition of glutaminase-1 (GLS-1) hampers the proliferation of tumor cells reliant on glutamine. Known glutaminase inhibitors have potential limitations, and in vivo exposures are potentially limited due to poor physicochemical...
8.
Goodwani S, Fernandez C, Acton P, Buggia-Prevot V, McReynolds M, Ma J, et al.
Int J Mol Sci
. 2020 Jul;
21(14).
PMID: 32659913
Dual leucine zipper kinase (DLK, Map3k12) is an axonal protein that governs the balance between degeneration and regeneration through its downstream effectors c-jun N-terminal kinase (JNK) and phosphorylated c-jun (p-c-Jun)....
9.
Goldstein D, Kuglstatter A, Lou Y, Soth M
J Med Chem
. 2009 Dec;
53(6):2345-53.
PMID: 19950901
No abstract available.
10.
Wipf P, Soth M
Org Lett
. 2002 May;
4(10):1787-90.
PMID: 12000299
[reaction: see text] The convergent synthesis of the fully functionalized C(1)-C(18) segment 24 of the furanocembranes lophotoxin and pukalide was accomplished in 11 steps and 10% overall yield. The key...