Michael J Properzi
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Explore the profile of Michael J Properzi including associated specialties, affiliations and a list of published articles.
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37
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938
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Recent Articles
1.
Coughlan G, Klinger H, Boyle R, Betthauser T, Binette A, Christenson L, et al.
JAMA Neurol
. 2025 Mar;
PMID: 40029638
Importance: Alzheimer disease (AD) predominates in females at almost twice the rate relative to males. Mounting evidence in adults without AD indicates that females exhibit higher tau deposition than age-matched...
2.
Birkenbihl C, Cuppels M, Boyle R, Klinger H, Langford O, Coughlan G, et al.
Brain Inform
. 2025 Jan;
12(1):3.
PMID: 39871006
Cognitive resilience (CR) describes the phenomenon of individuals evading cognitive decline despite prominent Alzheimer's disease neuropathology. Operationalization and measurement of this latent construct is non-trivial as it cannot be directly...
3.
Klinger H, Healy B, Hanseeuw B, Jones R, Boyle R, Townsend D, et al.
Alzheimers Dement
. 2024 Oct;
20(12):8728-8738.
PMID: 39470175
Introduction: While the influence of cross-sectional β-amyloid (Aβ) on longitudinal changes in cognition is well established, longitudinal change-on-change between Aβ and cognition is less explored. Methods: A series of bivariate...
4.
Birkenbihl C, Cuppels M, Boyle R, Klinger H, Langford O, Coughlan G, et al.
medRxiv
. 2024 Sep;
PMID: 39228697
Cognitive resilience describes the phenomenon of individuals evading cognitive decline despite prominent Alzheimer's disease neuropathology. Operationalization and measurement of this latent construct is non-trivial as it cannot be directly observed....
5.
Boyle R, Townsend D, Klinger H, Scanlon C, Yuan Z, Coughlan G, et al.
Alzheimers Res Ther
. 2024 Jul;
16(1):148.
PMID: 38961512
Background: Leveraging Alzheimer's disease (AD) imaging biomarkers and longitudinal cognitive data may allow us to establish evidence of cognitive resilience (CR) to AD pathology in-vivo. Here, we applied latent class...
6.
Rosenzweig N, Kleemann K, Rust T, Carpenter M, Grucci M, Aronchik M, et al.
Nat Med
. 2024 Jul;
30(10):2990-3003.
PMID: 38961225
APOE4 is the strongest genetic risk factor for Alzheimer's disease (AD), with increased odds ratios in female carriers. Targeting amyloid plaques shows modest improvement in male non-APOE4 carriers. Leveraging single-cell...
7.
Dubbelman M, Diez I, Gonzalez C, Amariglio R, Becker J, Chhatwal J, et al.
Front Aging Neurosci
. 2024 Jun;
16:1420290.
PMID: 38934017
Background: Changes in everyday functioning constitute a clinically meaningful outcome, even in the early stages of Alzheimer's disease. Performance-based assessments of everyday functioning might help uncover these early changes. We...
8.
Vascular contributions to cognitive decline: Beyond amyloid and tau in the Harvard Aging Brain Study
Shirzadi Z, Boyle R, Yau W, Coughlan G, Fu J, Properzi M, et al.
J Cereb Blood Flow Metab
. 2024 Mar;
44(8):1319-1328.
PMID: 38452039
In addition to amyloid and tau pathology, elevated systemic vascular risk, white matter injury, and reduced cerebral blood flow contribute to late-life cognitive decline. Given the strong collinearity among these...
9.
Premnath P, Locascio J, Mimmack K, Gonzalez C, Properzi M, Udeogu O, et al.
Alzheimers Dement (N Y)
. 2024 Feb;
10(1):e12442.
PMID: 38356477
Introduction: It is important to study apathy in Alzheimer's disease (AD) to better understand its underlying neurobiology and develop effective interventions. In the current study, we sought to examine the...
10.
Weizenbaum E, Soberanes D, Hsieh S, Molinare C, Buckley R, Betensky R, et al.
Neuropsychology
. 2023 Nov;
38(2):198-210.
PMID: 37971862
Objective: Unsupervised remote digital cognitive assessment makes frequent testing feasible and allows for measurement of learning over repeated evaluations on participants' own devices. This provides the opportunity to derive individual...