Michael J Parnham
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Explore the profile of Michael J Parnham including associated specialties, affiliations and a list of published articles.
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95
Citations
1983
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Recent Articles
11.
Parnham M, Kricker J
Int J Mol Sci
. 2022 Feb;
23(4).
PMID: 35216184
The plasticity of responses to drugs is an ever-present confounding factor for all aspects of pharmacology, influencing drug discovery and development, clinical use and the expectations of the patient. As...
12.
von Knethen A, Heinicke U, Laux V, Parnham M, Steinbicker A, Zacharowski K
Biomedicines
. 2022 Jan;
10(1).
PMID: 35052778
Acute respiratory distress syndrome (ARDS) is a major cause of patient mortality in intensive care units (ICUs) worldwide. Considering that no causative treatment but only symptomatic care is available, it...
13.
Sil A, Bespalov A, Dalla C, Ferland-Beckham C, Herremans A, Karantzalos K, et al.
Front Behav Neurosci
. 2021 Nov;
15:755812.
PMID: 34744655
Laboratory workflows and preclinical models have become increasingly diverse and complex. Confronted with the dilemma of a multitude of information with ambiguous relevance for their specific experiments, scientists run the...
14.
Kricker J, Page C, Gardarsson F, Baldursson O, Gudjonsson T, Parnham M
Pharmacol Rev
. 2021 Oct;
73(4):233-262.
PMID: 34716226
Macrolides are among the most widely prescribed broad spectrum antibacterials, particularly for respiratory infections. It is now recognized that these drugs, in particular azithromycin, also exert time-dependent immunomodulatory actions that...
15.
Niederberger E, Parnham M
Int J Mol Sci
. 2021 Jul;
22(14).
PMID: 34299312
It is well known that lifestyle changes can alter several physiological functions in the human body. For exercise and diet, these effects are used sensibly in basic therapies, as in...
16.
Schiffmann S, Gunne S, Henke M, Ulshofer T, Steinhilber D, Sethmann A, et al.
J Inflamm Res
. 2021 Jun;
14:2569-2582.
PMID: 34163212
Background: Sodium bituminosulfonate is derived from naturally occurring sulphur-rich oil shale and is used for the treatment of the inflammatory skin disease rosacea. Major molecular players in the development of...
17.
Ullmann T, Luckhardt S, Wolf M, Parnham M, Resch E
Int J Mol Sci
. 2021 Apr;
22(6).
PMID: 33809617
This study aimed to identify alternative anti-inflammatory compounds that modulate the activity of a relevant transcription factor, CCAAT/enhancer binding protein delta (C/EBPδ). C/EBPδ is a master regulator of inflammatory responses...
18.
Hering I, Eilebrecht E, Parnham M, Weiler M, Gunday-Tureli N, Tureli A, et al.
Aquat Toxicol
. 2021 Apr;
234:105798.
PMID: 33799113
A wide variety of active pharmaceutical ingredients are released into the environment and pose a threat to aquatic organisms. Drug products using micro- and nanoparticle technology can lower these emissions...
19.
Nieraad H, de Bruin N, Arne O, Hofmann M, Gurke R, Schmidt D, et al.
Int J Mol Sci
. 2021 Jan;
22(2).
PMID: 33477684
Hyperhomocysteinemia has been suggested potentially to contribute to a variety of pathologies, such as Alzheimer's disease (AD). While the impact of hyperhomocysteinemia on AD has been investigated extensively, there are...
20.
Gunne S, Heinicke U, Parnham M, Laux V, Zacharowski K, von Knethen A
Biomolecules
. 2020 Dec;
10(12).
PMID: 33348637
The transcription factor NF-E2 p45-related factor 2 (Nrf2) is an established master regulator of the anti-oxidative and detoxifying cellular response. Thus, a role in inflammatory diseases associated with the generation...